“Emerging leaders in redox biology”
The ECR subcommittee is hosting the “Emerging Leaders in Redox Biology” webinar series every first Tuesday of the month at 15:00 CET. Recordings of past webinars can be found in the society’s intranet pages.
Webinar series “Emerging leaders in redox biology”
6th February 2024 at 15:00 CET
Our next webinar will be on the topic “Redox signaling in cancer” featuring Salvatore Rizza and Hamed Alborzinia.
Redox Biology Group, Danish Cancer Institute, Copenhagen, Denmark
Salvatore Rizza is a senior researcher in the lab of Giuseppe Filomeni at the Danish Cancer Institute. His research has centered on redox stress and specifically on the study of GSNOR, a pivotal enzyme regulating the levels of proteins covalently modified by the cellular messenger nitric oxide (NO). In 2016, Salvatore uncovered a crucial link between the absence of GSNOR and mitochondrial respiration, pinpointing SDH as a vulnerability in a subset of tumors. Building on this, he shifted focus to GSNOR dynamics during cell senescence and aging, elucidating the age-dependent GSNOR decline orchestrated by DNA methylation and demethylation reactions. This decline was intricately tied to mitochondrial aberrations, shedding light on the aging process. Further expanding this exploration, he delved into the interplay of NO-signaling and mitochondria homeostasis in immune cells and discovered that under oxidative stress, GSNOR induction led to decreased S-nitrosylation levels, boosting mitophagy and supporting the viability of immune cells facing excessive oxidative and nitrosative stress during activation. In 2023, Salvatore and his colleagues unveiled the prevalence of GSNOR deficiency in most solid tumors, triggering FAK1 hyperactivation and promoting anchorage-independent cell growth. This insight has significant therapeutic implications, as FAK1 inhibitors emerge as potential agents to exploit this vulnerability, effectively positioning GSNOR as a novel therapeutic efficacy marker in cancer research.
Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany
Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, GermanyRegulation of cell adhesion and anoikis by S-nitrosylation
Hamed Alborzinia graduated in veterinary medicine from Shiraz University (Iran) before enrolling in the Molecular Biology Ph.D. program at Heidelberg University. During his doctoral studies in Heidelberg, he utilized bioanalytical techniques to investigate cancer cell metabolism. In 2018, he joined the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) and the Division of Stem Cells and Cancer at the German Cancer Research Center (DKFZ) within the lab of Prof. Andreas Trumpp in Heidelberg, Germany. As a Postdoctoral researcher, his primary focus has been on unraveling the metabolic properties of cancer cells, particularly in relation to emerging forms of cell death, such as ferroptosis. Recently appointed as a group leader at HI-STEM/DKFZ, Hamed's main objective is to explore cell death mechanisms in cancer cells, with a specific emphasis on drug resistance. His research group is actively involved in uncovering the novel metabolic cell death pathway of ferroptosis, with the ultimate aim of identifying therapeutic strategies for challenging cancers, including those characterized by MYC deregulation and drug tolerance.
6 February 2024
Aging and Cancer
6 February 2024
5 March 2024
Grant writing and patents
2 April 2024
Circadian rhythm and redox state
2 April 2024
7 May 2030
Webinar of 9th January 2024 on the topic “Redox mechanisms in plants” featuring Jan-Ole Niemeier and José Manuel Ugalde
Redox Relay Race: PhD students on the move
The ECR subcommittee also hosted in 2023 the first PhD student mini Symposium to give opportunities to PhD students to present their work. The selection of the speakers was done based on a short video presentation about their work: