SFRR-E VISITING FELLOWSHIPS / Early Career Investigator Travel Awards
SFRR-Europe Visiting Fellowships (Prior "Early Career Investigator Travel Awards") are sponsored by ELSEVIER on behalf of FRBM and Redox Biology, and are awarded to Early Career Investigators to cover travel and accommodation expenses during a short research stay in another laboratory in Europe.
SFRR-E VISITING FELLOWSHIPS
2019 Ambra Antonioni (Italy)
2019 Pablo Martí-Andrés (Spain)
Early Career Investigator Travel Awardee 2018
GIORGIA DI BELLO
Giorgia di Bello was born in Foggia (Italy) in 1989. She graduated at the University of Bari in 2014, writing a thesis about the insulin resistance related to mitochondrial calcium. Soon, after graduating, she started to work at the University of Padova (Prof. Rizzuto’s Lab). Thanks to this fellowship, she collaborated with the University of Davis (UC Davis, California, USA, Prof. Cortopassi’s Lab). Here she spent three months reseraching into small molecules screening of MCU interactors and calcium modulators.
At the end of 2015, Giorgia started her PhD at the University of Foggia (Dept. of Medical and Surgical Sciences, Prof. Serviddio’s Lab). Her PhD project focused on the in vitro and in vivo experiments to study the molecular mechanisms involved in the activation/differentiation of Hepatic Progenitor Cells (HPCs) during chronic liver injury. Indeed, nowadays, stem cells-based therapies are being developed in this field to avoid the negative aspects related to the liver transplant as well as liver transplant-related disadvantages.
In May 2018, Giorgia won the Early Career Travel Award sponsored by Elsevier, which enabled her to spend the final period of her PhD at MRC-Mitochondrial Biology Unit in Cambridge (UK). Here she worked in Biochemistry World (Prof. Murphy’s Lab) where she dealt in particular with the development of new methods to tag mitochondrial protein thiols changes in oxidative stress.
• Redox cell signaling and hepatic progenitor cells. di Bello G, Vendemiale G, Bellanti F., Eur J Cell Biol. 2018 Nov;97(8):546-556. doi: 10.1016/j.ejcb.2018.09.004.
• Increased mitochondrial calcium uniporter in adipocytes underlies mitochondrial alterations associated with insulin resistance. Lauren E. Wright, Denis Vecellio Reane, Gabriella Milan, Anna Terrin, Giorgia di Bello, Anna Belligoli, Marta Sanna, Mirto Foletto, Francesca Favaretto, Anna Raffaello, Cristina Mammucari, Donato Nitti, Roberto Vettor, Rosario Rizzuto. American Journal of Physiology - Endocrinology and Metabolism Published 8 August 2017 Vol. no. , DOI: 10.1152/ajpendo.00143.2016.
• Synergistic interaction of fatty acids and oxysterols impairs mitochondrial function and limits liver adaptation during NAFLD progression”. Gaetano Serviddio, Luigi Iuliano, Carlo Avolio, Gianluigi Vendemiale, Francesco Bellanti, Rosanna Villani, Rosanna Tamborra, Maria Blonda, Giuseppina Iannelli, Giorgia di Bello, Antonio Facciorusso, Giuseppe Poli. Redox Biol. 2018 May;15:86-96. doi: 10.1016/j.redox.2017.11.016.
Early Career Investigator Travel Awardees 2017
Department of Clinical and Biological Sciences
University of Torino
San Luigi Gonzaga Hospital
10043 Orbassano, Torino (Italy)
Erica Staurenghi was born in Torino, Italy, in 1991. She graduated in Medical Biotechnology at the University of Torino in 2015 working on a project concerning the neuro-inflammatory, pro-oxidant and pro-amiloidogenic effects of some cholesterol oxidation products, named oxysterols, in Alzheimer’s disease. The same year she started her PhD in Experimental Medicine and Therapy at the University of Torino, supervised by Professor Gabriella Leonarduzzi. In the first two years of her PhD she focused on the correlation between brain oxysterol levels and Alzheimer’s disease progression, investigating the role of the redox-sensitive deacetylase sirtuin-1 as well.
She received the SFRR-E Early Career Investigator Travel Award 2017 to support her stay at the Maurice Wohl Clinical Neuroscience Institute (King’s College London), where she is currently working in the laboratory of Dr Wendy Noble with the aim of investigating the effect of some oxysterol mixtures on astrocyte reactivity, one of the main hallmark of Alzheimer’s disease brain.
Testa G, Staurenghi E, Giannelli S, Gamba P, Gargiulo S, Tamagno E, Guglielmotto M, Tabaton M, Leonarduzzi G. A silver lining for 24-hydroxycholesterol in Alzheimer’s disease: the involvement of the neuroprotective enzyme sirtuin 1. 2018, Currently Under Submission.
Gargiulo S, Testa G, Gamba P, Staurenghi E, Poli G, Leonarduzzi G. Oxysterols and 4-hydroxy-2-nonenal contribute to atherosclerotic plaque destabilization. Free Radic. Biol. Med., 2017, 111: 140-150.
Testa G, Staurenghi E, Zerbinati C, Gargiulo S, Iuliano L, Giaccone G, Fantò F, Poli G, Leonarduzzi G, Gamba P. Changes in brain oxysterols at different stages of Alzheimer’s disease: their involvement in neuroinflammation. Redox Biology, 2016, 10: 24-33.
Vurusaner B, Gamba P, Gargiulo S, Testa G, Staurenghi E, Leonarduzzi G, Poli G, Basaga H. Nrf2 antioxidant defense is involved in survival signaling elicited by 27-hydroxycholesterol in human promonocytic cells. Free Radic. Biol. Med., 2016, 91: 93-104.
Gamba P, Testa G, Gargiulo S, Staurenghi E, Poli G, Leonarduzzi G. Oxidized cholesterol as the driving force behind the development of Alzheimer's disease. Front. Aging Neurosci., 2015, 7:119.
Isabela Finamor was born in 1986 in Santiago (Brazil). She graduated in Biomedicine at the Universidade Luterana do Brasil (Brazil) in 2007 and obtained her PhD in Pharmacology at the Universidade Federal de Santa Maria (Brazil) in 2015 doing a doctoral thesis on aspartame-induced glutathione depletion in rats and mice under the supervision of Prof. Maria Amalia Pavanato. During her thesis, she spent six months in the lab of Prof. Juan Sastre, Universidad de Valencia (Spain), where she identified that aspartame triggers glutathione depletion due to an impairment in its synthesis, blocking the trans-sulphuration pathway. She started her PostDoc in 2015 also in the lab of Prof. Sastre, who was interested in protein cysteinylation, an important feature of disulfide stress in inflammation. So, she performed in vitro studies with a biotinylated probe for cysteinylation and found a marked increase in protein cysteinylation in thioredoxin related protein of 14 kDa (TRP14) knock-down cells. For this reason, she received the SFRR-E Early Career Investigator Award 2017 sponsored by Elsevier on behalf of Redox Biology to support her travel and stay in the laboratory of Dr. Elias Arnér in the Karolinska Institute as host institution with the aim of investigating the role of TRP14 in regulating protein function through control of cysteinylated Cys residues.
I. Finamor, S. Pérez, C.A. Bressan, C.E. Brenner, S. Rius-Pérez, P.C. Brittes, G. Cheiran, M.I. Rocha, M. da Veiga, J. Sastre, M.A. Pavanato, Chronic aspartame intake causes changes in the trans-sulphuration pathway, glutathione depletion and liver damage in mice, Redox Biol. 11 (2017) 701–707. doi:10.1016/j.redox.2017.01.019.
I. Finamor, G.M. Ourique, T.S. Pês, E.M.H. Saccol, C.A. Bressan, T. Scheid, B. Baldisserotto, S.F. Llesuy, W.A. Partata, M.A. Pavanato, The protective effect of N-acetylcysteine on oxidative stress in the brain caused by the long-term intake of aspartame by rats, Neurochem. Res. 39 (2014) 1681–1690. doi:10.1007/s11064-014-1360-9.
S. Pérez, S. Rius-Pérez, I. Finamor, P. Martí-Andrés, I. Prieto, R. García, M. Monsalve, J. Sastre, Obesity causes PGC-1α deficiency in the pancreas leading to marked IL-6 upregulation via NF-κB in acute pancreatitis, J. Pathol. 247 (2019) 48–59. doi:10.1002/path.5166.
S. Pérez, S. Rius-Pérez, A.M. Tormos, I. Finamor, Á.R. Nebreda, R. Taléns-Visconti, J. Sastre, Age-dependent regulation of antioxidant genes by p38α MAPK in the liver, Redox Biol. 16 (2018) 276–284. doi:10.1016/j.redox.2018.02.017.
S. Rius-Pérez, A.M. Tormos, S. Pérez, I. Finamor, P. Rada, Á.M. Valverde, A.R. Nebreda, J. Sastre, R. Taléns-Visconti, p38α deficiency restrains liver regeneration after partial hepatectomy triggering oxidative stress and liver injury, Sci. Rep. 9 (2019) 3775. doi:10.1038/s41598-019-39428-3.
Early Career Travel Awardees 2016
RAÚL GONZÁLEZ OJEDA
Raul Gonzalez Ojeda was born in Cordoba, Spain, in 1978. He graduated in Biology at the University of Cordoba, and obtained his PhD in 2011 doing a Doctoral Thesis on the antioxidant treatment against to oxidative stress and cell death in cultured human hepatocytes supervised by Dr. Jordi Muntane Relat. During the Doctoral phase he has realized various scientific stays in the Institut National de la Sante et de la Recherche Medicale (INSERM U-632, Montpellier, France) and Immunology Department in La Princesa University Hospital (Madrid, Spain). Between the years 2012-2015 he worked in Biochemistry Department of Cordoba University in the proteomic analysis of different proteins related to intracellular signaling pathways in vitro and in vivo study models. Nowadays, he has a Research Postdoctoral Contract Juan de la Cierva de Formacion in the group "Surgical Oncology, Regenerative Medicine y Cell Therapy” of the Biomedicine Institute of Seville (IBIS). Where he takes part in the research of the regulation of cell death and proliferation and its relationship with the therapeutic effectiveness on the hepatocellular carcinoma, the evaluation of the therapeutic effectiveness of Sorafenib and immunosuppression in the hepatocellular carcinoma (HCC), and the search of biomarkers in the cholangiocarcinoma. He has published about 30 papers included in the Journal of Citations Reports on effect of antioxidants on liver damage with in vivo and in vitro approaches, post-translational modifications in different proteins involved in cell death and signaling pathway, and study of different strategies against liver damage as HCC and cholangiocarcinoma.
Department of Molecular Toxicology
German Institute of Human Nutrition
14558 Nuthetal, Germany
Martín Hugo was born in Nueva Helvecia, Uruguay, in 1984. He graduated in Biochemistry at Universidad de la República and obtained his PhD in Biological Sciences in 2014 doing a doctoral thesis on enzymes involved in the detoxification of reactive oxygen species in intracellular pathogens, under the supervision Prof. Rafael Radi and Madia Trujillo. During his thesis, a novel subfamily of peroxiredoxins present in Mycobacterium tuberculosis, specialized in the detoxification of lipid hydroperoxides was described, and a novel mycothiol-dependent pathway for the reduction of the enzyme was found. In Trypanosoma cruzi, a novel function and subcellular localization of a heme peroxidase with relevance in parasite virulence was discovered. His main research interests are the mechanisms of cysteine modification and its role in enzyme regulation. In 2014 he joined the Molecular Toxicology group headed by Prof. Tilman Grune at the German Institute of Human Nutrition where he is currently applying cysteine-targeted proteomics to understand the regulation of the proteasomal system by cysteine modification in pancreatic b-cells. He received the SFRR-E Early Career Investigator Award 2016 sponsored by Elsevier on behalf of FRBM to support his travel and stay in the laboratory of Dr. Antonio Martínez-Ruiz in the Princesa Health Research Institute as host institution.
Hugo M, Martínez A, Trujillo M, Estrada D, Mastrogiovani M, Linares E, Augusto O, Issoglio F, Zeida A, Estrín D, Heijnen HFG, Piacenza L, Radi, R. Kinetics, subcellular localization and contribution to parasite virulence of a Trypanosoma cruzi hybrid type A heme peroxidase (TcAPx-CcP). PNAS 2017
Randall LM, Manta B, Hugo M, Gil M, Batthyàny C, Trujillo M, Poole LB, Denicola A. Nitration transforms a sensitive peroxiredoxin 2 into a more active and robust peroxidase. J Biol Chem. 2014
Martinez A, Peluffo G, Petruk AA, Hugo M, Piñeyro D, Demicheli V, Moreno DM, Lima A, Batthyány C, Durán R, Robello C, Martí MA, Larrieux N, Buschiazzo A, Trujillo M, Radi R, Piacenza L. Structural and molecular basis of the peroxynitrite-mediated nitration and inactivation of Trypanosoma cruzi iron-superoxide dismutases (Fe-SODs) A and B: disparate susceptibilities due to the repair of Tyr35 radical by Cys83 in Fe-SODB through intramolecular electron transfer. J Biol Chem. 2014
Hugo M, Van Laer K, Reyes AM, Vertommen D, Messens J, Radi R, Trujillo M. Mycothiol/mycoredoxin 1-dependent reduction of the peroxiredoxin AhpE from Mycobacterium tuberculosis. J Biol Chem. 2014
Reyes AM, Hugo M, Trostchansky A, Capece L, Radi R, Trujillo M. Oxidizing substrate specificity of Mycobacterium tuberculosis alkyl hydroperoxide reductase E: kinetics and mechanisms of oxidation and overoxidation. Free Radic Biol Med. 2011
Hugo M, Turell L, Manta B, Botti H, Monteiro G, Netto LE, Alvarez B, Radi R, Trujillo M. Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics. Biochemistry. 2009