Society for Free Radical Research - Europe

November news from the ECR subcommittee

Dear colleagues, 

In today's newsletter, we are excited to announce the final webinar of the season discussing Redox methods and the launch of the call for new ECR fellowships. We will also share with you a summary of November's webinar and of the PhD symposium. At the end of the newsletter, as always, you can also find a collection of upcoming events with important deadlines, some suggestions of interesting redox reads recently published, open call for papers and job opportunities for young redox researchers.

Next Webinar series “Emerging leaders in redox biology”

The final webinar of the year will take place on December 3rd, 2024, at 15:00 CET, focusing on the important topic “Redox methods” with featured speakers James Cobley and Rafael Argüello.

Oxiforms: Redox biology at the proteoform level

James Cobley, PhD
School of Life Sciences, University of Dundee, Dundee, United Kingdom

After studying the redox aspects of sports supplements as an exercise physiology student, James Cobley joined Abertay University (Dundee) to research the biology of reactive oxygen species (ROS) in the nervous system, with a particular focus on synapse pruning. During this time, he visited the lab of Prof. Michael Murphy to learn the art of measuring ROS, particularly mitochondrial superoxide using MitoNeD. Thereafter, James joined the University of the Highlands and Islands (Inverness) to study cysteine redox biology using microplate-based techniques and developed the idea of oxiforms: cysteine redox proteoforms. Presently, James is post-doctoral researcher in the lab of Prof. Angus Lamond at Dundee University. There, James is applying mass spectrometry based proteomics to analyse adipose tissue from identical and non-identical human twins, using the Astral machine. He is also working on methods to measure cysteine redox proteoforms using mass spectrometry.

Decoding complexity: A closer look at stress, metabolism and epigenetic crosstalks through Epic-SCENITH and SNUPR

Rafael Argüello, PhD
Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France

Rafael J. Argüello is tenured research associate at CNRS (Marseille) and the inventor of SCENITHTM, a method for metabolic profiling with single cell resolution. A molecular biologist with a PhD in Human Immunology from Argentina (UBA) and postdoctoral work at CIML and UCSF, his research now focuses on stress, metabolism and epigenetics in immune cells. His awards include the 2021 Diversity-Equity and Inclusion Paper of the Year 2021. He co-founded GammaOmics, a startup developing personalized medicine tools, is active in the non-profit-Expedición Ciencia, and is a co-founding member of the European ImmunoMetabolism Network.

 

ECR Fellowships - New call open!!

If you are an ECR member of the SFRR-E and under 40 years of age in one of the following situations:

  • Postdoc (minimum 3 years after the completion of your PhD).
  • Scientist returning to academia after a career break
  • Scientist less than 3 years into your first academic position.

You can apply to one of the SFRR-E/OCC ECR Fellowships! These fellowships provide funding up to 10.000€ for a 12-month period supporting research or seed-funding for a new project relevant for the redox field.

If you are interested in applying, please submit your application via the SFRR-E intranet. Deadline: 20th December 2024.

More information as well as the application form are available in the members area of the SFRR-E web: https://intranet.sfrr-europe.org


Good luck to you all!


New ECR subcommittee members - call open until the 29th November!


The ECR subcommittee is looking for new members! Are you interested in joining a vibrant redox community trying to support young researchers in the redox field? We have open spots in the following committees: social media team, newsletter team, webinar team and mentoring program.

If you are less than 40 years old and/or you have defended your PhD thesis less than 10 years ago and you would like to contribute to the redox ECR community, we are looking forward to meeting you!

The call is now open until the 29th November 2024.

You can apply by filling out this form: https://www.surveymonkey.com/r/LPMHD6C or directly reach out to us if you have questions!

 

Second Edition of the PhD Redox Relay Online Symposium:

On the 19th November six enthusiastic PhD students showcased their research at the 2nd Edition of our PhD Symposium!

Each presenter did an excellent job presenting their PhD projects in just 5 minutes! The symposium covered a diverse range of topics, from aging and sports science to the cutting-edge field of persulfides and chronic diseases. The students presented their data with enthusiasm, shared their ideas with confidence, and tackled even the toughest questions with ease.

It was a real pleasure listening to them and if this is the future of redox biology, we are very excited for the years to come!

Please acknowledge our brave PhD students!

If you missed it, you can find the symposium on the society’s intranet!

 

November's webinar:

On November's webinar we enjoyed two great talks on the topic “Redox in Photosynthetic organisms” by Sophie Hendrix and Libero Gurrieri.

Glutathione peroxidase-like 8 (GPXL8): A new player in hydrogen peroxide signalling in Arabidopsis thaliana?

Sophie Hendrix, PhD
Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium
Department of Biology, University of Antwerp, Antwerp, Belgium

Do you feel the heat? Plant cells depend on an extensive antioxidant defense network to keep reactive oxygen species (ROS) at sub-toxic levels. One member of this network is glutathione peroxidases (GPX). In mammalian cells, GPXs detoxify hydrogen peroxide (H2O2) via the GSH/GR/NADPH redox relay, while plant GPXs, in contrast, use the TRX/NTR/NADPH redox relay, and therefore named GPX-like proteins or GPXLs. Dr. Sophie Hendrix shared with us the potential role of a GPXL in alleviating heat-induced ferroptosis plants. A type of programmed cell death dependent on Iron that is well understood in mammal cells but with limited information in plants. Moreover, Dr. Hendrix proved that this GPXL can work as a new H2O2 sensor in vitro and in vivo. Using different variants of this GPXL, they have gained further insight into the importance of each of its conserved cysteines in establishing the protein’s oxidoreductase activity. These new discoveries contribute to elucidating the function of uncharacterized plant GPXLs and open the possibility of generating new redox sensors for H2O2.

Redox control of starch degradation interlaces glutathione, thioredoxins and guard cell function

Libero Gurrieri, PhD
Molecular Plant Physiology Lab, Department of Pharmacy and Biotechnology, University of Bologna, Italy

Take a breath! Plants use stomata as pores for gas exchange, letting carbon dioxide (CO2) in for carbon fixation and water out as vapor. Stomata opening and closing are mediated by a pair of guard cells that, in turn, are controlled by multiple factors, including starch degradation. Starch is the carbohydrate reserve that plants build during the day and use during the night when photosynthesis is not possible. Starch degradation leads to ATP production, which activates ion channels that ultimately change the cell water potential, facilitating stomata closure. In this webinar, Dr. Libero Gurrieri presented his work on characterizing BAM1, a chloroplast beta-amylase regulated by redox. BAM1 is inactive upon forming an intramolecular disulfide bond and active when reduced. He proved that mutant lines for chloroplastic glutathione reductase (GR) have more degraded starch, indicating increased amylase activity, and they are currently following the hypothesis that GSH can glutathionylate BAM1, protecting it from redox inactivation. The following research will focus on the connection between the redox-regulated amylase activity and stomata opening, reinforcing the redox-gas exchange link in plant leaves.


More information about the ECR Subcommittee can be found on the SFRR-E website (ECR Committee), while regular updates can be found on Twitter (@SFRR_Europe), Instagram (@sfrr_ecr) and LinkedIn (SFRR-E). For any question or suggestion you might have, you can contact us via email: This email address is being protected from spambots. You need JavaScript enabled to view it..

Hope to see you online for our next Webinar Series appointment,

The ECR subcommittee

Upcoming events:

22nd SFRRI Biennial Meeting

The New Era of Redox Biology: from Basic Biochemistry to Redox Omics
3 - 6 June 2025
Location: Galway, Ireland
Deadlines:
Travel Grant Applications: 10 January 2025
Abstract Submission: 10 February 2025
Early Bird Registration: 31 March 2025
Further information: https://www.sfrrgalway2025.com

 

FASEB Science Research Conference. Ferroptosis, Oxidative Stress, and Lipid Metabolism

27 - 31 July 2025
Location: Scottsdale, Arizona
Deadlines:
Abstract Submission: 1 June 2025
Early Registration: 15 June 2025
Housing: 13 July 2025
Further information: https://events.faseb.org/event/11797f9e-df16-42b9-9c47-f1e06713c4fb/summary 

 

Interesting Redox Papers:

Lang, L., Reinert, P., Diaz, C. & Deponte, M. The dithiol mechanism of class I glutaredoxins promotes specificity for glutathione as a reducing agent. Redox Biol (2024). https://doi.org/10.1016/j.redox.2024.103410

Fiorenza, M., Onslev, J., Henríquez-Olguín., C., et al. Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans. Sci Adv (2024). https://doi.org/10.1126/sciadv.adq4461

Sarah Barakat, Şeyma Çimen, Ş, Miri, SM., et al. Bioenergetic shift and proteomic signature induced by lentiviral-transduction of GFP-based biosensors. Redox Biol (2024). https://doi.org/10.1016/j.redox.2024.103416

Pérez-Chávez, I., Koberstein, J.N., Malo Pueyo, J., et al. Tracking fructose 1,6-bisphosphate dynamics in liver cancer cells using a fluorescent biosensor. iScience (2024). https://doi.org/10.1016/j.isci.2024.111336

Choudhary, D., Foster, K.R. & Uphoff, S. The master regulator OxyR orchestrates bacterial oxidative stress response genes in space and time. Cell Syst (2024) https://doi.org/10.1016/j.cels.2024.10.003

Ito, J., Nakamura, T., Toyama, T., et al. PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization. Mol Cell (2024). https://doi.org/10.1016/j.molcel.2024.10.028

Ryu, K.W., Fung, T.S., Baker, D.C., et al. Cellular ATP demand creates metabolically distinct subpopulations of mitochondria. Nature (2024). https://doi.org/10.1038/s41586-024-08146-w

Chen, Z., Inague, A., Kaushal, K. et al. PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance. Mol Cell (2024). https://doi.org/10.1016/j.molcel.2024.10.027

Gomes, F., Turano, H., Haddad, L.A. & Netto, L.E.S. Human mitochondrial peroxiredoxin Prdx3 is dually localized in the intermembrane space and matrix subcompartments. Redox Biol (2024) https://doi.org/10.1016/j.redox.2024.103436

Pace, P.E., Fu, L., Hampton, M.B. & Winterbourn, C.C.. Redox proteomic analysis of H2O2 -treated Jurkat cells and effects of bicarbonate and knockout of peroxiredoxins 1 and 2. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.10.314

 

Insightful Redox Reviews:

Zachary J. Rogers, Z.J., Flood, D. & Taylor, C.T. Oxygen control in cell culture – your cells may not be experiencing what you think! Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.11.036

 Sies, H. SFRRI Inaugural Alberto Boveris Award Lecture Dynamics of Intracellular and Intercellular Redox Communication. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.11.002

Jackson, MJ. Exercise-induced adaptations to homeostasis of reactive oxygen species in skeletal muscle. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.10.270

José Viña, J., Borrás, C. & Mas-Bargues, C. Free radicals in Alzheimer's disease: From pathophysiology to clinical trial results. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.09.051

Duong, L.D., West, J.D. & Morano, K.A. Redox Regulation of Proteostasis. J Biol Chem (2024). https://doi.org/10.1016/j.jbc.2024.107977

 

Lastest Redox Preprints:

Agostinis, P., Rizzollo, F., Escamilla-Ayala, A., et al. A Bdh2-driven Lysosome to Mitochondria Iron Trafficking Controls Ferroptosis in Melanoma. Research Square (2024). https://doi.org/10.21203/rs.3.rs-5345588/v1 

 

Call for papers:

Journal: Free Radical Biology and Medicine
Special Issue: Redox medicine: Translation of Basic science to the Clinic
Submission deadline: 1 March 2025
More information: https://www.sciencedirect.com/special-issue/314690/redox-medicine-translation-of-basic-science-to-the-clinic

  

Redox Job Opportunities:

Postdoc positions


• Kind of position: Postdoc (2 years)
• Research topic: Physiology and Pharmacology
• Institute/University: Karolinska Institute, Stockholm
• Deadline: 31st January 2025
• Contact information: This email address is being protected from spambots. You need JavaScript enabled to view it.
• Further information about the position: We are searching for someone skilled in biochemistry and/or chemical biology. Knowledge in EPR technique is highly appreciated.


• Kind of position: Postdoc (3 years)
• Research topic: Post-translational Modifications and Proliferation
• Institute/University: The Institute of Cancer Research, London ( Dr. Jörg Mansfeld Lab)
• Deadline: 15th December 2024 (Interviews January 2025)
• Contact information: This email address is being protected from spambots. You need JavaScript enabled to view it.
• Further information about the position: we are seeking a highly motivated and ambitious candidate for a Postdoctoral Training Fellow position, with experience in cell cycle research, ubiquitin, or redox biology. A strong cell biology or biochemistry background with an emphasis on the regulation of protein-protein interactions and mechanistic studies in vitro or in cells is highly desirable. Knowledge in DNA replication and/or DNA damage repair is desirable.
• Lab webpage: https://www.mansfeldlab.com
• To apply:
https://jobs.icr.ac.uk/vacancies/1059/postdoctoral-training-fellow--post-translational-modifications-and-cell-proliferation.html

 

PhD positions

• Kind of position: PhD position (4 years)
• Research topic: Understanding intracellular redox heterogeneity - www.kritsiligkou.com
• Institute/University: The University of Liverpool
• Deadline: 31 December 2024
• Contact information: This email address is being protected from spambots. You need JavaScript enabled to view it.
• Further information about the position: A PhD position (fully funded for UK students only) is available at the lab of Dr P. Kritsiligkou. Please contact them directly for more information on how to apply.

Remember that if there’s an open position in your lab for early career researchers and you would like to advertise it in our newsletter, just write us an email (This email address is being protected from spambots. You need JavaScript enabled to view it.) containing the following information:

• Kind of position: (PhD student, Postdoc, etc)
• Research topic
• Institute/University
• Deadline
• Contact information
• Further information about the position (if any)


SFRR-E ECR 2nd PhD Mini Symposium

This Tuesday 19th November at 15:00 CET six talented postgraduate researchers will present their work at the 2nd PhD Mini Symposium!

1. Abril Gorgori - Harmol as a nutritionalstrategy to improve aged mitochondria

2. Javier Huete Acevedo - Extracellular vesicles from adipose derived stem cells from young mice improve cognition in old mice

3. Marta Arnal - Differential content of small extracellular vesicles obtained from plasma of young, old and centenarian humans

4. Roberto Andrés Meneses Valdés - Spatiotemporal manipulation of hydrogen peroxide as a novel model for skeletalmuscle wasting in mouse muscle

5. Danny Schilling - The emerging role of protein persulfides in biology

6. Martina Ciarnelli - Study of the immunometabolic alterations in the monocyte/macrophage system in chronic diseases

Join us to celebrate the work of the new generation of redox scientists!

https://us06web.zoom.us/j/86469731540?pwd=cQW0yK5sNCPXO5sSOcaoBHaZPy2Tu8.1 

Passcode: 433382

More information about the ECR Subcommittee can be found on the SFRR-E website ECR Committee, while regular updates can be found on Twitter (@SFRR_Europe), Instagram (@sfrr_ecr) and LinkedIn (SFRR-E). For any question or suggestion you might have, you can contact us via email: This email address is being protected from spambots. You need JavaScript enabled to view it..

Hope to see you online, 
The ECR subcommittee

October news from the SFRRE ECR subcommittee

Dear colleagues,

In today's newsletter, we will announce November's webinar, the new edition of our PhD symposium and the opening of the call for new ECR subcommittee members. We will also share with you a summary of October’s webinar and the winners of the YIA of the Spetses Redox Summer School. At the end of the newsletter, as always, you can also find a collection of upcoming events with important deadlines, some suggestions of interesting redox reads recently published, open call for papers and job opportunities for young redox researchers.


Next Webinar series “Emerging leaders in redox biology”

Our next webinar will be on 5th November 2024 at 15:00 CET on the topic “Redox in Photosynthetic organisms” featuring Sophie Hendrix and Libero Gurrieri.


Glutathione peroxidase-like 8 (GPXL8): A new player in hydrogen peroxide signalling in Arabidopsis thaliana?


Sophie Hendrix, PhD

Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium
Department of Biology, University of Antwerp, Antwerp, Belgium

In 2019, Sophie Hendrix obtained her PhD in Biology from Hasselt University (Belgium) under the supervision of Prof. Ann Cuypers. Her doctoral research focused on plant responses to cadmium stress with a particular emphasis on cell cycle regulation and the DNA damage response. Following her PhD, she was awarded an EMBO short-term fellowship to work in the lab of Prof. Andreas Meyer at the University of Bonn (Germany), where she gained experience with genetically-encoded biosensors to study redox dynamics in cadmium-exposed plants. In 2020, she obtained an Alexander von Humboldt postdoctoral fellowship to continue her research at the University of Bonn. During her postdoc, she studied molecular plant responses to heat stress and investigated the involvement of plant glutathione peroxidase-like proteins in redox signalling. She then moved back to Hasselt University, where she continued her postdoctoral work with an SFRR-E Early Career Researcher fellowship. In 2023, she was appointed as an assistant professor at the Centre for Environmental Sciences of Hasselt University. Her current work focuses on dissecting molecular plant responses to combined stress conditions, using Arabidopsis as a model system. Furthermore, she aims to further elucidate the functions of plant glutathione peroxidase-like proteins in plant stress responses.



Redox control of starch degradation interlaces glutathione, thioredoxins and guard cell function


Libero Gurrieri, PhD


Molecular Plant Physiology Lab, Department of Pharmacy and Biotechnology, University of Bologna, Italy


Libero obtained his PhD in Molecular and Cellular Biology at the University of Bologna in 2019. He is currently a junior researcher at the Department of Pharmacy and Biotechnology (University of Bologna, Italy) in the Molecular Plant Physiology Lab, where he held two postdoctoral positions, while he was lecturer at the University of Ferrara (Italy). Libero is investigating the role of post-translational redox modifications on plant enzymes involved in primary carbon metabolism. To gain insight into the basis of redox regulation, his comprehensive approach goes from the protein to the atom, thanks to many collaborations with structural scientists, then validating in plants the in vitro results. He started focusing on how thiol switches control the Calvin-Benson cycle, and recently he is exploring how glutathione-based modifications can modulate starch metabolism. Starch is a primary source of carbon in plants and plays an increasingly important role in gas exchange, providing carbon skeletons and energy to open stomata pores on the leaf surface.


Second Edition of the PhD Redox Relay Online Symposium - SAVE THE DATE! 19th November 2024 at 15:00 CET

It’s our pleasure to present to you the second edition of our PhD Symposium!

For this edition six enthusiastic PhD students will present their work:

1. Roberto Meneses-Valdés, University of Copenhagen
2. Marta Arnal, University of Valencia
3. Martina Ciarnelli, University of Foggia
4. Abril Gorgori, University of Valencia
5. Javier Huete, University of Valencia
6. Danny Schilling, German Cancer Research Center

The PhD symposium will take place online on the 19th November 2024 at 15:00 CET. Please mark that in your calendars!

A detailed newsletter with all the PhD symposium and speakers information will follow, stay tuned!


New ECR subcommittee members - call now open!

If you are less than 40 years old and/or you have discussed your PhD thesis less than 10 years ago and you would like to contribute to the redox ECR community, we have great news for you! We are looking for new members for our ECR subcommittee!

The call is now open until the 29th November 2024.

You can apply by filling out this form: https://www.surveymonkey.com/r/LPMHD6C 

 
October’s webinar:

On October’s webinar we enjoyed an insightful talk on the topic “Peer review process” by Mike Davies:

Insights into the peer review and publication of scientific papers


Mike Davies, Professor

Department of Biomedical Sciences, University of Copenhagen, Denmark

In October’s webinar, Prof. Michael Davies shared with us his editorial long-lasting trajectory and leading role in the main journals in the field of Redox Biology. In particular, he gave highly valuable insights on the peer review process, the independent evaluation of research papers by experts in the field before publishing. We all, as scientists, will be involved in this process as authors or as evaluators! Some of the main editors´ tasks include the assessment of the suitability of a manuscript for the journal, the identification of potential reviewers and the decision-making on manuscript consideration, while some reviewers’ commitments are to prove fair and timely commentaries on new potential manuscripts within their area of expertise. Of note, Prof. Davies valued the importance of this process to get an advanced version of research work as well as acknowledged and encouraged all scientists to get involved in this system, including early career researchers.


Spetses Redox Summer School 2024 - Young Investigator Awards

We would like to highlight the three young researchers that got a SFRR-E Young Investigator Award for their great presentations at the Spetses Redox Summer School 2024: Anne Sophie Scheller (Germany), Felix Schmidt (Germany) and Karoline Scholzen (Sweden). Congratulations to all the awardees!!


More information about the ECR Subcommittee can be found on the SFRR-E website (ECR Committee), while regular updates can be found on Twitter (@SFRR_Europe), Instagram (@sfrr_ecr) and LinkedIn (SFRR-E). For any question or suggestion you might have, you can contact us via email: This email address is being protected from spambots. You need JavaScript enabled to view it..

Hope to see you online for our next Webinar Series appointment,

The ECR subcommittee


Upcoming events:

SfRBM 2024 Conference

  • 31st Annual Conference
  • 20 - 23 November 2024
  • Location: Savannah, Georgia, USA
  • Deadlines:
    • Abstract and Awards Deadline: already closed
    • Early Registration Deadline: 15 October 2024
  • Further information: https://sfrbm.org/meetings/sfrbm-2024/ 


22nd SFRRI Biennial Meeting

  • The New Era of Redox Biology: from Basic Biochemistry to Redox Omics
  • 3 - 6 June 2025
  • Location: Galway, Ireland
  • Deadlines:
    • Travel Grant Applications: 10 January 2025
    • Abstract Submission: 10 February 2025
    • Early Bird Registration: 31 March 2025
  • Further information: https://www.sfrrgalway2025.com 


Interesting Redox Papers:

Keeney, M.T., Rocha, E.M., Hoffman, E.K., et al. LRRK2 regulates production of reactive oxygen species in cell and animal models of Parkinson’s disease. Sci Transl Med (2024). https://doi.org/10.1126/scitranslmed.adl3438 

Zheng, H., Chen, H., Cai, Y., et al. Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer. Mol Cell (2024). https://doi.org/10.1016/j.molcel.2024.08.035 

Katopodi, V., Marino, A., Pateraki, N., et al. The long non-coding RNA ROSALIND protects the mitochondrial translational machinery from oxidative damage. Cell Death Differ (2024). https://doi.org/10.1038/s41418-024-01377-4 

Wang, S., Liu, M., Hu, D., et al. Control of DNA demethylation by superoxide anion in plant stem cells. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01737-8 

Liang, F., Zandkarimi, F., Lee, J., et al. OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response. Mol Cell (2024). https://doi.org/10.1016/j.molcel.2024.07.020 

Ersoy, U., Altinpinar, A.E., Kanakis, I., et al. Lifelong dietary protein restriction induces denervation and skeletal muscle atrophy in mice. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.09.005 

Qiao, Z., Nguyen, L.C., Yang, D., et al. Direct inhibition of tumor hypoxia response with synthetic transcriptional repressors. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01716-z

Bian, Y., Shan, G., Guoshu, B. Targeting ALDH1A1 to enhance the efficacy of KRAS-targeted therapy through ferroptosis. Redox Biol (2024). https://doi.org/10.1016/j.redox.2024.103361 

 

Insightful Redox Reviews:

Decker, S.T. & Funai, K. Mitochondrial membrane lipids in the regulation of bioenergetic flux. Cell Metab (2024). https://doi.org/10.1016/j.cmet.2024.07.024 

Donato, L., Mordà, D., Scimone, C., et al. From powerhouse to regulator: The role of mitoepigenetics in mitochondrion-related cellular functions and human diseases. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.03.025 

Meneses-Valdés, R., Gallero, S., Henríquez-Olguín, C. & Jensen, T.E. Exploring NADPH oxidases 2 and 4 in cardiac and skeletal muscle adaptations – A cross-tissue comparison. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.07.035 

Vilas-Boas, E.A. & Kowaltowski, A.J. Mitochondrial redox state, bioenergetics, and calcium transport in caloric restriction: A metabolic nexus. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.04.234 

Margaritelis, N.V., Cobley, J.N., Nastos, G.G., et al. Evidence-based sports supplements: A redox analysis. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.08.012 

 

Lastest Redox Preprints:

Hecht, F., Zocchi, M., Tuttle, E.T., et al. Catabolism of extracellular glutathione supplies amino acids to support tumor growth. BioRxiv (2024). https://doi.org/10.1101/2024.10.10.617667 

Cobley, J.N., Noble, A. & Guille, M. Cleland immunoblotting unmasks unexpected cysteine redox proteoforms. BioRxiv (2024). https://doi.org/10.1101/2024.09.18.613741 

Vorhauser, J., Roumeliotis, T. I., Leung, J. K., et al. Cell cycle-dependent S-sulfenyl proteomics uncover a redox switch in p21-CDK feedback governing the proliferation-senescence decision. BioRxiv (2024). https://doi.org/10.1101/2024.09.14.613007 

Moss, D. Y., Brown, C., Shaw, A., et al. Mitochondrial metabolism is a key determinant of chemotherapy sensitivity in Colorectal Cancer. BioRxiv (2024). https://doi.org/10.1101/2024.09.12.611189 

Rothemann, R.A., Pavlenko, E., Mondal, E., et al. Interaction with AK2A links AIFM1 to cellular energy metabolism. BioRxiv (2024). https://doi.org/10.1101/2024.09.09.611957 

 

Call for papers:

Journal: Free Radical Biology and Medicine

 

Redox Job Opportunities:

If there’s an open position in your lab for early career researchers and you would like to advertise it in our newsletter, just write us an email (This email address is being protected from spambots. You need JavaScript enabled to view it.) containing the following information:

• Kind of position: (PhD student, Postdoc, etc)
• Research topic
• Institute/University
• Deadline
• Contact information
• Further information about the position (if any)


September news from the SFRRE ECR subcommittee

Dear colleagues,

We are ready to go back to work again! In today's newsletter, we will announce the timeline of our next webinar series and October’s webinar, the opening of the call of our editorial mentoring programme, the call of our PhD symposium, and the call for travel awards for the next SFRR-I meeting in Galway. At the end of the newsletter, as always, you can also find a collection of upcoming events with important deadlines and some suggestions of interesting redox reads recently published so you will be ready for “back to school”.

Next Webinar series “Emerging leaders in redox biology”

We have great news to share with you, our webinars will be back! Our next webinar series will begin on 8th October with a very important topic for ECRs: the peer review process.

Other topics during this series will be on redox methods, H2S signaling and chaperones in redox biology. We haven’t forgotten that some of you work in the plant field so we also have a special webinar about redox in photosynthetic organisms. For people interested in redox biology and health we have one webinar about environmental stressors in cardiovascular diseases and another one on nutrition and exercise. And in May 2025, the mental health awareness month, we will have a special webinar on this very important topic.

More information will follow in the next newsletters, stay tuned!

 

Our next webinar will be on 8th October 2024 at 15:00 CET on the topic “Peer review process” featuring Mike Davies.

Insights into the peer review and publication of scientific papers

Mike Davies, Professor

Department of Biomedical Sciences, University of Copenhagen, Denmark


Michael (Mike) Davies has worked in the UK (University of York and Brunel University), Australia (The Heart Research Institute, Sydney) and Denmark (University of Copenhagen - his current position) during his career.
He was previously Editor-in-Chief of 'Free Radical Research' for 10 years, and is currently Co-Editor-in-Chief of 'Redox Biochemistry and Chemistry' and an Editor for 'Biochemistry and Biophysical Research Communications' and a long-standing editorial board member of 'Redox Biology' and 'Free Radical Biology and Medicine' amongst others. He also acts as Scientific Integrity and Ethics Editor for a group of Elsevier journals including 'Redox Biology'. He has previously served as President of SFRR-Australasia, Secretary-General and President of SFRR-International, and President of SFRR-Europe. His research group examines the mechanisms and consequences of protein oxidation and extracellular matrix modification, the detection and quantification of post-translational modifications (e.g. by LC-MS proteomics), the role of redox processes in human pathologies and particularly cardiovascular diseases.


ECR Editorial Mentoring Programme: call opened on 23rd September!

We are happy to announce the first edition of the new Editorial Mentoring Programme.
It is a programme that aims to offer ECRs the opportunity to increase their engagement with scientific publishing (SFRR-Europe official journals) and gain experience in editorial board work and manuscript handling. The programme will run over the year 2025 for 12 months. Selected participants will be paired with one of the Editorial Board members of one of SFRR-Europe's official journals and will receive 1 to 1 training and mentoring.

Further information about the application process and selection criteria can be found in the member’s intranet of the SFRR-E website: https://intranet.sfrr-europe.org

The call opened on the 23rd September and the deadline is on the 18th October.

We believe it’s an incredible opportunity for ECRs and hope that many of you will apply!


Second Edition of the PhD Redox Relay Online Symposium - call opens in October!

We are preparing the second edition of the PhD symposium. If you are a PhD student and would like to show the results of your project to the redox community, you can’t miss this call.

The format consists of online flask-talks of 5 minutes for presentation and 2 minutes for Q&A.

The call will open in the beginning of October, the deadline will be on the 15th October. Selected participants will be notified by the 25th October. The PhD Symposium will take place online on the 19th November.

It’s a great opportunity for PhD students to present their work and get valuable feedback.

 

Travel awards to attend the SFRR-I Galway Meeting 2025 - call already open!

If you enjoyed SFRR-E Meeting this year in Istanbul as much as we did, you can’t miss next year’s meeting! It will be a great opportunity for sharing your work and for networking because next year, the SFRR-E will be organising the SFRR-I biennial meeting, which means a lot of researchers from outside Europe will be attending.

Who can apply?

Students or postdocs members of SFRR-E.

To which awards can I apply?

    • Travel awards of 400€ each for PhD students
    • Travel awards of 400€ each for postdocs (less than 5 years after your PhD and not in permanent academic positions).
    • Travel awards of 900€ for non-European students or postdocs who require transoceanic or long-distance travel to attend the meeting. (You can also apply to this if you are a member of a SFRR Regional Society).

How to apply?

Applicatoins should be submitted online through the SFRR-E intranet (https://intranet.sfrr-europe.org, Call for Travel Awards in the menu on the left) as a single PDF containing:

    • CV (max 2 pages, include date of PhD award if applicable).
    • Supporting letter writteng by the aplicant (outlining your interest and motivation for attending the meeting)
    • Abstract for the communciation to be presented at the conference.

Important dates:

The deadline to recive submissions is on 10th January 2025.

Announcement of the awardees: before early-bird registration.

Applicant must submit their abstracts online thought the conference website (https://www.sfrrgalway2025.com) before 10th February 2025.

 

If you need further information, you can contact This email address is being protected from spambots. You need JavaScript enabled to view it..

More information about the ECR Subcommittee can be found on the SFRR-E website ( ECR Committee (sfrr-europe.org ), while regular updates can be found on Twitter (@SFRR_Europe), Instagram (@sfrr_ecr) and LinkedIn (SFRR-E). For any question or suggestion you might have, you can contact us via email: This email address is being protected from spambots. You need JavaScript enabled to view it..

Hope to see you online for our next Webinar Series appointment,

The ECR subcommittee


Upcoming events:

HNE Club Meeting



11th Biennial Meeting of the Society for Free Radical Research-Asia (SFRR-Asia 2024) Club Meeting

“The new era of precision redox biology and medicine: from basic research to the intervention of aging and diseases”

 

SfRBM 2024 Conference

    • 31st Annual Conference
    • 20 - 23 November 2024
    • Location: Savannah, Georgia, USA
    • Deadlines:
      • Abstract and Awards Deadline: already closed
      • Early Registration Deadline: 15 October 2024
    • Further information: https://sfrbm.org/meetings/sfrbm-2024/

  

22nd SFRRI Biennial Meeting

    • The New Era of Redox Biology: from Basic Biochemistry to Redox Omics
    • 3 - 6 June 2025
    • Location: Galway, Ireland
      • Deadlines:
      • Travel Grant Applications: 10 January 2025
      • Abstract Submission: 10 February 2025
      • Early Bird Registration: 31 March 2025
    • Further information: https://www.sfrrgalway2025.com



Interesting Redox Papers:

Asantewaa, G., Tuttle, E.T., Ward, N.P., et al. Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression. Nat Commun (2024). https://doi.org/10.1038/s41467-024-50454-2

Esteban-Collado, J., Fernández-Mañas, M., Fernández-Moreno, M., et al. Reactive oxygen species activate the Drosophila TNF receptor Wengen for damage-induced regeneration. EMBO J (2024). https://doi.org/10.1038/s44318-024-00155-9


Schwab, A., Rao, Z., Zhang, J., et al. Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition. Nat Cell Biol (2024). https://doi.org/10.1038/s41556-024-01464-1


Bonetti, L., Horkova, V., Grusdat, M., et al. A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation. Cell Metab (2024). https://doi.org/10.1016/j.cmet.2024.06.010


Lorito, N., Subbiani, A., Smiriglia, A., et al. FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer. EMBO Mol Med (2024). https://doi.org/10.1038/s44321-024-00090-6


Insightful Redox Reviews:

Furrer, R. & Handschin, C. Molecular aspects of the exercise response and training adaptation in skeletal muscle. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.07.026


Berndt, C., Alborzinia, H., Amen, V.S., et al. Ferroptosis in health and disease. Redox Biol (2024). https://doi.org/10.1016/j.redox.2024.103211


Akaike, T., Morita, M., Ogata, S., et al. New aspects of redox signaling mediated by supersulfides in health and disease. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.07.007


Nakamura, T. & Conrad, M. Exploiting ferroptosis vulnerabilities in cancer. Nat Cell Biol (2024). https://doi.org/10.1038/s41556-024-01425-8


Mialet-Perez, J. & Belaidi, E. Interplay between hypoxia inducible Factor-1 and mitochondria in cardiac diseases. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.04.239



Welcome Back from the SFRR-E ECR subcommittee

Dear colleagues, 

We hope you have had a fantastic summer and if you’re still on holidays, we envy you! We are ready to go back to work again! In today's newsletter, we will share with you the highlights of the annual SFRR-E Meeting in Istanbul.

Highlights of the Events organized by the ECR Subcommittee at the SFRR-E Meeting in Istanbul:

The last annual meeting of the SFFR-E took place in Istanbul, 5-7 June 2024 and we organized multiple exciting events dedicated to ECRs (and not only)!

1) ECR networking event (Wednesday 5th June at 18:30, Hall 2).

On the first evening of the conference we enjoyed our yearly ECR networking event. We started by making teams based on our famous stickers that you love so much! After a brief introduction of yourselves to break the ice, we continued by playing in teams a challenging puzzle game in which only the best teams got to go ahead to the next rounds. At the end, the remaining team was proclaimed the winners and got the prize.
It was hilarious seeing all of you discussing the solutions for the different puzzles and chasing our juries to advance to the next round! We hope you all had a lot of fun together and enjoyed making new connections.

 

  

2) Meet-the-Professors session (Wednesday 5th June, at 19:30, Hall 2).

On Wednesday evening, after the ECR networking event, we had the “Meet the Professors” session, open to everybody.

We welcomed 9 professors and group leaders with diverse areas of expertise: Daniela Caporossi, Niki Chondrogianni, Andreas Daiber, Mike Davies, Isabel Fabregat, Clare Hawkins, Malcolm Jackson, João Laranjinha, Giuseppe Valacchi and David Heppner.

We started with a brief introduction of the careers of our guests to get to know all of them and, afterwards, teams were formed including one of our special guests per team! We gave each team pasta and marshmallows and the hard task of building a tower. The team who built the highest tower with our fancy construction materials would be the winner!!

It was very funny seeing all of you teaming up together and even laying on the ground very concentrated on building the tower. It was impressive how some of the teams applied the most innovative building techniques!!

3) Sunrise Round Table I: Pillow Talks: From Academia to Industry (Thursday 6th June at 8:00, Hall 2).

On Thursday we began the morning with a sunrise round table, open for early birds and everybody who was not tired after a networking night.

Experts from academia (Antonio Cuadrado, Giuseppe Valacchi and Kasia Whysall) and industry (Mike Lu, Sven Terclavers and Carmen Veith) were there to discuss diverse career paths. Thank you all for the participation!

Everybody asked their questions about how it is working in either one of these sectors and it was very interesting knowing the pros and cons of each side. It is clear that career perspectives is a very important topic for ECRs and that many of you are very interested about this topic when you are at the end of your PhDs or while during your postdocs. For this reason we are planning on organising more events like that for ECRs!

4) Sunrise Round Table II: ROS Measurement: From Bedside to Bench (Friday 7th June at 8:00, Hall 2).


On Friday morning, we prepared a sunrise round table, open for everybody, focused on how to measure ROS. We were happy that many people joined, ECRs and not, considering also the early hour!

For this event we were honoured to have experts in ROS measurements (Michael Davies, Clare Hawkins, Giovanni Mann, Jan Riemer and Hadley D. Sikes). Our chairs (Veronica Lisi and Timoteo Marchini) organised a novel fishbowl set up which greatly helped to keep the dynamic of the event.

We were happy to see that how to measure ROS in an accurate way was such an important topic for you all, senior and not, and the very interesting debates originated during the round table.

5) ECR-Symposium: H2O2 on the Move: from Sub-cellular Redox Signals to Therapeutic Potential (Friday 7th June at 9:00, Hall 1).


On Friday morning, after the sunrise round table, we had our first symposium within the SFRR-E Annual Meeting organized only by ECRs. The symposium was chaired by Cristina Mas-Bargues and Carmen Veith. David Heppner, Rut Espinosa, Carlos Henriquez Olguin and Carmen Veith discussed a lot about NADPH oxidases in different contexts and diseases as well as subcellular hydrogen peroxide compartmentalization.

It was great seeing so many people at the symposium, interested in the work of our invited speakers. We deeply believe that it is inspirational for ECRs seeing the work of their peers at similar stages of their careers.

We also got to acknowledge the young researchers that presented great science at the meeting. The SFRR-E gave 6 awards to Irene Canovas-Cervera (Spain), Javier Marques (Spain), Ufuk Ersoy (UK), Attila Altinpinar (UK), Lea Strohm (Germany) and Konstantinos Papanikolaou (Greece). Congratulations to all the awardees!!

We had an incredible time together during the SFRR-E conference and it was very motivating seeing so many people enjoying our events and helping us build an ever growing community of young redox researchers!

The ECR subcommittee says a big THANKS! to everybody who attended our events, see you next year in Galway between 3 - 6 June 2025! You can already find details about the 2025 meeting in https://www.sfrrgalway2025.com.



More information about the ECR Subcommittee can be found on the SFRR-E website (ECR Committee (sfrr-europe.org), while regular updates can be found on Twitter (@SFRR_Europe), Instagram (@sfrr_ecr) and LinkedIn (SFRR-E). For any question or suggestion you might have, you can contact us via email: This email address is being protected from spambots. You need JavaScript enabled to view it..

Stay tuned for the next newsletter, it will be full with new information for ECRs!

The ECR subcommittee

SFRR-E

The Society for Free Radical Research - Europe (SFRR-E) is dedicated to promoting interest in all aspects of research related to Free Radicals in any scientific field.

cookies

This website uses cookies to improve your experience. By accessing this site you agree to use them. We'll assume you are OK with this, but you can opt-out if you wish.
Información sobre ley de cookies. Este sitio web utiliza cookies para guardar información en su ordenador. Algunas de estas cookies son necesarias para el correcto funcionamiento de la web. Al utilizar nuestro sitio usted acepta las condiciones de uso y nuestra política de privacidad.