How to write a Great Research Paper, and Get it Accepted by a Good Journal. By Anthony Newman from Elsevier

Jobs

PostdocJobs.com

 

Postdoctoral Fellow/Research Associate

Job Description

Come join a new lab at Georgetown University exploring links between cancer and heart disease!
Dr. Nanette Bishopric, an expert in oxidative stress and its impact on myocardial celll life and death decisions, is starting a new laboratory dedicated to understanding how stress-related factors remodel transcription to worsen outcomes in both breast cancer and heart failure. Dr. Bishopric’s lab is offering a funded postdoctoral position through the Lombardi Comprehensive Cancer Center and the Dept. of Oncology, with specific emphases on acetyltransferases, microRNA dysregulation and ectopic ATP synthase activity as key modulators of breast cancer metastasis, and the impact of novel cancer therapies on cardiac health.
A talented postdoctoral recruit will be able to pursue and expand these projects, using mouse models, clinical specimens, bioinformatics and functional studies of cancer metabolism. Research efforts will be further supported by the Department of Comparative Medicine, which provides state-of-the-art facilities for studies involving immunocompetent and immunocompromised animals, animal breeding and genotyping, and is equipped with in vivo imaging capabilities to non-invasively monitor disease progression and metastasis.
Applicants with experience in murine models of cancer metastasis, gene editing, immunohistochemistry, bioinformatics, and molecular signalling will be particularly competitive. Individuals with experience related to drug development and toxicology are also encouraged to apply. Successful candidates will be expected to demonstrate excellent written and oral communication skills, strong teamwork, and independent work habits. Applicants will be expected to multitask and solve problems as part of a dynamic lab group.
The current funded position requires U.S. citizenship (or green card).

Interested in applying? please send a cover letter, resume, and names of references to Prof. Nanette H. Bishopric at nhb20@georgetown.edu.

 

Postdoctoral Research Scientist

Job Description

Job Description
Title: Postdoctoral Research Scientist position - Laboratory of Dr. Joseph Garcia
Job Family: Research (Laboratory and Non-Laboratory)
Minimal Degree Required: MD or PhD

The Cardiovascular Research Program at Columbia University Irving Medical Center is recruiting a full-time Postdoctoral Research Scientist position in the laboratory of Dr. Joseph Garcia. We seek a well-trained and highly motivated scientist to work in close coordination with existing program members. The laboratory employs novel mammalian cell and animal models generated by CRISPR/Cas9 and conditional knockout technologies to study stress signaling induced by oxygen and dietary manipulations. We seek a highly recommended scientist to further our efforts in understanding molecular mechanisms underlying this stress signaling pathway and to define its role in mammalian physiology and pathophysiology. With the resources currently available, we expect that these projects will bridge multiple biomedical fields of high interest. We anticipate that the postdoctoral research experience will lead to exciting opportunities in academia, research or industry.
The Postdoctoral candidate will be involved with a range of activities, including:
• Design of experiments, demonstration of rigor and creativity in experimentation
• Molecular biology activities including cloning, mutagenesis, plasmid purification
• Mammalian tissue culture, transfection, and stable cell line experiments
• Lentiviral construction, growth, and use
• Mouse husbandry and breeding, Animal experiments involving oxygen and diet manipulation
• Development and Maintenance of Organoid bodies and Primary cells derived from mice
• Tissue histology, Immunofluorescence analysis, Confocal and Light microscopy
• Nucleic acid, Protein, Metabolite isolation from mammalian cells and tissues
• Enzymatic measurements of protein and metabolites from mammalian cells and tissue
• Quantitative rtPCR, Immunoblot, and Immunofluorescence analyses of mammalian samples
• Deep sequencing, Epigenetic analysis of mammalian cell and tissue, microbiome samples
• Data summary, Statistical analysis, Implementation of workflow improvements
Qualifications:
• Education (MD and/or PhD) and experience in a relevant field, such as molecular biology, genetics, nutrition, integrative physiology, biochemistry or pharmacology
• Prior and significant experience with a majority of activities listed above
• A publication record that reflects an ability to function as a skilled and developing scientist
• Excellent oral and written English communication skills
• Ability to adapt to a fast-paced and dynamic environment
• Ability to work effectively in a team and Attention to detail are necessary
• Prompt organization and storage of primary data is required
Accurate and timely documentation of laboratory efforts is mandatory.
To Apply: Please send your Cover Letter and Curriculum Vitae to Joseph A. Garcia, MD, Professor of Medicine
Department of Medicine/Cardiology jag2369@cumc.columbia.edu

 

Postdoctoral Associate

Job Description

A postdoctoral position is available in the laboratory of Dr. Danica Chen in Program in Metabolic Biology, Nutritional Science & Toxicology (https://nst.berkeley.edu/users/danica-chen) and Berkeley Stem Cell Center (http://stemcellcenter.berkeley.edu/DanicaChen.html) at UC Berkeley to study aging and diseases of aging including but not limited to stem cell biology, metabolic biology, and mitochondrial biology. The applicants must have a Ph.D. in biomedical sciences or related field, or a M.D. with research experience. Applicants should submit curriculum vitae, including list of publications, a description of their present research activity and contact information for three referees to: danicac@berkeley.edu.

 

 

Postdoctoral Associate - Molecular and Human Genetics

  • Baylor College of Medicine

  • Location: Houston, TX

  • Job Number: 7055964 (Ref #: 307627KP)

  • Posting Date: Feb 14, 2019

  • Application Deadline: Open Until Filled

Job Description

Seeking postdoctoral associate to work on project focused on cancer biology and mitochondrial metabolism.  The position requires the ability to lead projects and work cooperatively with others, carry out and troubleshoot experiments, and assist in grant and manuscript writing. Candidate will have the opportunity to do both basic science and translational research as they work in a fast-paced research environment. Postdocs with bioinformatics backgrounds that are looking to learn wet lab techniques are also encouraged to apply.

Required:

  • PhD in basic science or equivalent.

  • Experience in standard molecular & biological techniques, cell culture, and animal models.

  • Must be self-motivated and have a strong background in standard molecular and biological techniques, cell culture, and animal models.

Preferred:   Previous experience in breast cancer or mitochondrial biology.

 

For more information visit:  https://www.bcm.edu/people/view/benny-kaipparettu-ph-d/b1915357-ffed-11e2-be68-080027880ca6

MITOCHONDRIA IN CANCER AND CANCER HEALTH DISPARITIES


Job Description

A postdoctoral position is available in Singh's MITODESIGN LAB at the Department of Genetics at the University of Alabama, Birmingham (UAB). Our group has a longstanding interest in understanding the role of mitochondrial genetics in human diversity, mitochondria-to-nucleus retrograde crosstalk, numtogenesis (nuclear mitochondrial biogenesis), mitonuclear genomic instability in cancer and cancer health disparities.
We have an excellent academic environment and research facilities at the Department of Genetics. UAB is a major research university and academic health center that offers a highly interactive scientific environment with state-of-the-art research and core facilities and multidisciplinary work environment. The Department of Genetics fosters collaborations with other basic science as well as clinical departments and the UAB Comprehensive Cancer Center.
The candidate is expected to be self-motivated, resourceful and should have a recently obtained a Ph. D degree. Those with interest and experience in mitochondrial biology, biogenesis, and genetics, epigenetics such as DNA methylation and mouse and cell culture models of cancer and/or human diseases are strongly encouraged to apply.
The candidate must have experience in mitochondrial techniques, OXPHOS enzymatic assays, cell culture, and standard molecular and epigenetic techniques including cloning, real-time PCR, transfection, Southern, Northern and Western analysis and immunoprecipitation. The candidate with experience in tumorigenesis assays such as soft agar, matrigel invasion, and mouse xenograft is also preferred. The successful candidate is expected to design and perform experiments and interpret data independently.
Interested applicants should email a cover letter with the description of research interests and experience, curriculum vitae, and contact information of three references (in pdf format) to kksingh@uab.edu
Keshav K. Singh, Ph.D.
Joy and Bill Harbert Endowed Chair
Professor of Genetics, Pathology and Environmental Health
Department of Genetics, UAB School of Medicine
The University of Alabama at Birmingham
Kaul Genetics Building, Rm. 620
720 20th St. South
Birmingham, AL 35294
The University of Alabama at Birmingham is an equal opportunity, affirmative action employer with a strong commitment to ethnic and cultural diversity among its faculty, students and staff. Applications from women and ethnic minorities are encouraged.


Contact Us: kksingh@uab.edu

 

Postdoctoral Research Scholar

Job Description

MITOCHONDRIA IN CANCER: MECHANISMS OF CHEMORESISTANCE
A postdoctoral position is available at the Department of Radiation Oncology and the Free Radical Biology Program at the University of Iowa. Our group has a longstanding interest in understanding the role of mitochondrial in the development and progression of malignant brain cancer. The University of Iowa is a major research university and academic health center that offers a highly interactive scientific environment with state-of-the-art research and core facilities and multidisciplinary work environment.

The Free Radical Biology Program is a division of the Department of Radiation Oncology and is part of the Holden Comprehensive Cancer Center and the Carver College of Medicine. It is the only PhD granting program at the University of Iowa that is located in a clinical department. Since the Department of Radiation Oncology currently treats more than 1,500 cancer patients a year, this allows our trainees to have unique training opportunities for basic science that rapidly moves into translational research.

Qualifications: The candidate is expected to be self-motivated, resourceful and should have a recently obtained a Ph.D. degree. Those with interest and experience in mitochondrial biology, biogenesis, and genetics, epigenetics such as DNA methylation and mouse and cell culture models of cancer and/or human diseases are strongly encouraged to apply.

The candidate must have experience in mitochondrial techniques, OXPHOS enzymatic assays, cell culture, and standard molecular and epigenetic techniques including cloning, real-time PCR, transfection, Southern, Northern and Western analysis and immunoprecipitation. The candidate with experience in tumorigenesis assays such as soft agar, matrigel invasion, and mouse xenograft is also preferred. The successful candidate is expected to design and perform experiments and interpret data independently.

Trainee Commitment: Postdoctoral Scholars must dedicate at least 40 hours per week (full-time effort) to the training program. These scholar appointments are 12-month appointments; however appointments may be renewed for additional one-year increments, contingent upon available funding and satisfactory performance. Trainees are expected to take on a leadership/mentorship role in the laboratory for both undergraduate and graduate students.

How to Apply: To apply, please visit http://jobs.uiowa.edu/, requisition# 3102. Applicants should attach a cover letter, curriculum vitae, a description of their research program, and current contact information for 3 potential references.

Interested applicants should contact Dr. Corinne Griguer via email and include a cover letter with description of research interests and experience, curriculum vitae, and contact information of three references (in pdf format) - corinne-griguer@uiowa.edu

The University of Iowa is an equal opportunity/affirmative action employer. All qualified applicants are encouraged to apply and will receive consideration for employment free from discrimination on the basis of race, creed, color, national origin, age, sex, pregnancy, sexual orientation, gender identity, genetic information, religion, associational preference, status as a qualified individual with a disability, or status as a protected veteran.

 

 

 

EURAXES

 

PhD student in science (physics, biology, chemistry, biochemistry, pharmacy)

  • ORGANISATION/COMPANY

Université de Namur

  • RESEARCH FIELD

Biological sciences › Biology

Chemistry › Biochemistry

Chemistry › Organic chemistry

Physics › Applied physics

  • RESEARCHER PROFILE

First Stage Researcher (R1)

  • APPLICATION DEADLINE

07/04/2019 23:00 - Europe/Brussels

  • LOCATION

Belgium › Namur

  • TYPE OF CONTRACT

Temporary

  • JOB STATUS

Full-time

  • HOURS PER WEEK

38

  • OFFER STARTING DATE

08/04/2019

 

The Laboratory of Evolutionary Genetic and Ecology (LEGE), in collaboration with the Laboratory of Analysis by Nuclear Reaction (LARN), is carrying out a research project on micro-organisms (rotifers) resistance to the environment of the international space station (ISS) (gamma rays, charged particles, UV, vacuum exposure, etc.). In this context, rotifers are irradiated on ground and will be stored in a module outside ISS. In addition, these rotifers have outstanding anti-oxidant defenses. Moreover in a previous research, the LARN has also shown that gold nanoparticles used in vitro increase oxidative stress in human cells. The interaction between gold nanoparticles and rotifers has not yet been studied.

Contact to

Hiring/Funding Organisation/Institute

  • ORGANISATION/COMPANY

Université de Namur

  • DEPARTMENT

Physics - LARN

  • ORGANISATION TYPE

Higher Education Institute

  • WEBSITE

http://www.unamur.be

  • E-MAIL

anne-catherine.heuskin@unamur.be

  • COUNTRY

Belgium

  • CITY

Namur

  • POSTAL CODE

5000

  • STREET

Rue de Bruxelles, 61

  • PHONE

0032 81 72 54 77

  • FAX

0032 81 72 54 74


Development of a therapeutic strategy based on ER and oxidative stress to target Acute Myeloid Leukemia

  • ORGANISATION/COMPANY

Università degli studi di Roma la Sapienza - Dipartimento di Scienze Anatomiche, Istologiche, Medico Legali e dell'Apparato Locomotore

  • RESEARCH FIELD

Biological sciences › Biology

  • RESEARCHER PROFILE

First Stage Researcher (R1)

Recognised Researcher (R2)

Established Researcher (R3)

Leading Researcher (R4)

  • APPLICATION DEADLINE

25/03/2019 23:59 - Europe/Brussels

  • LOCATION

Italy

  • TYPE OF CONTRACT

To be defined

 

Up to know the only targeted therapy for AML is based on Retinoic Acid (RA) and arsenic trioxide (ATO) that results in a highly successful cure for Acute Promyelocytic Leukemia. However other types of AML do not respond. In this context, we devised a strategy based on the combination of the differentiating agent RA in combination with ER stress and oxidative stress inducers that efficiently causes cell death of differentiating APL cell lines and primary human blasts isolated from patients and treated ex vivo, without affecting normal hematopoietic progenitors (Masciarelli et al., 2018, Leukemia 32, 285–294).
We are now extending our studies to non-APL AML. The successful candidate will explore the efficacy of the combination of ER and oxidative stress on AML cells in vitro and in vivo, in humanized mouse models, and the underlying molecular mechanisms by classical and high throughput approaches.

Contact to

Hiring/Funding Organisation/Institute

  • ORGANISATION/COMPANY

Università degli studi di Roma la Sapienza - Dipartimento di Scienze Anatomiche, Istologiche, Medico Legali e dell'Apparato Locomotore

  • ORGANISATION TYPE

Higher Education Institute

  • WEBSITE

http://servizi.saimlal.uniroma1.it/drupaluni/bandi_categoria_tendina/all

https://web.uniroma1.it/trasparenza/dettaglio_bando_albo/139127

  • COUNTRY

Italy

  • CITY

Roma




Postdoctoral Fellow in Cell Biology

ORGANISATION/COMPANY

University of Alberta

  • RESEARCH FIELD

Biological sciences

Chemistry

Medical sciences

  • RESEARCHER PROFILE

First Stage Researcher (R1)

  • APPLICATION DEADLINE

31/03/2019 00:00 - Europe/Athens

  • LOCATION

Canada › Edmonton

 

A postdoc position is available immediately to study calcium and redox signaling between the Endoplasmic Reticulum and Mitochondria. The successful applicant will be studying the function of redox-sensitive ER proteins in this mechanism. These proteins localize to ER-mitochondria contact sites dependent on oxidation and reduction of cysteines. Candidate proteins, identified by the lab previously, will have to be mechanistically characterized using yeast and mammalian cell culture.

More details and application instructions:

https://www.lifescience.net/jobs/39955/postdoctoral-fellow-in-cell-biology/

 

Contact to

Hiring/Funding Organisation/Institute

  • ORGANISATION/COMPANY

University of Alberta

  • ORGANISATION TYPE

Other

  • COUNTRY

Canada

  • CITY

Edmonton


PhD position within the EU Project Secreters (m/f) - limited for three years-192831

  • ORGANISATION/COMPANY

Boehringer Ingelheim RCV GmbH & Co KG

  • RESEARCH FIELD

Biological sciences › Biological engineering

  • RESEARCHER PROFILE

First Stage Researcher (R1)

  • APPLICATION DEADLINE

20/03/2019 00:00 - Europe/Brussels

  • LOCATION

Austria › Vienna

  • TYPE OF CONTRACT

Temporary

  • JOB STATUS

Full-time

  • HOURS PER WEEK

38

  • EU RESEARCH FRAMEWORK PROGRAMME

H2020 / Marie Skłodowska-Curie Actions

  • MARIE CURIE GRANT AGREEMENT NUMBER

813979


Contact to

Hiring/Funding Organisation/Institute

  • ORGANISATION/COMPANY

Boehringer Ingelheim RCV GmbH & Co KG

  • ORGANISATION TYPE

Large Company

  • WEBSITE

https://www.boehringer-ingelheim.at/de

  • COUNTRY

Austria

  • CITY

Vienna

  • POSTAL CODE

1121

  • STREET

Dr. Boehringer-Gasse 5-11


Post-doctoral position in Medicinal Chemistry, CDD polyphenol/PUFA chemistry

  • ORGANISATION/COMPANY

CNRS

  • RESEARCH FIELD

Biological sciences

Chemistry

Pharmacological sciences

  • RESEARCHER PROFILE

Recognised Researcher (R2)

  • APPLICATION DEADLINE

11/03/2019 23:59 - Europe/Brussels

  • LOCATION

France › MONTPELLIER

  • TYPE OF CONTRACT

Temporary

  • JOB STATUS

Full-time

  • HOURS PER WEEK

35

  • OFFER STARTING DATE

02/05/2019

 

In order to further study the mechanism of action of this LEAD and to discover effective lipophenols by oral administration, the postdoctoral fellow will be required to
- synthesize new lipophenols in order to carry out a structure-activity relationship (SAR) study.
- carry out anti-oxidant and carbonyl tests, on cell lines of the retinal pigment epithelium (ARPE-19), in collaboration with Dr. P. Brabet, specialist in retinal pathologies (Institute of Neurosciences of Montpellier) .

The project concerns the development of new treatments to fight retinal degeneration (AMD or Stargardt). These pathologies result from oxidative and carbonyl stressors (COS), which accumulate within the retinal tissue. To develop new therapeutics treatment, new drugs must be designed to effectively trap oxidative and carbonyl stressors and selectively target the retinal tissue. No treatment is currently available for the dry form of AMD.

The postdoctoral fellow will be involved in a medicinal chemistry program requiring the synthesis of different series of lipophenols as well as the evaluation of their antioxidant and anti-carbonyl stress properties (anti-COS) in retinal pigment epithelium cell lines. The design of anti-COS derivatives is based on the structural modification of natural polyphenols to modulate their nucleophilic and antioxidant properties. Two series of alkyl polyphenols conjugated with omega-3 polyunsaturated fatty acids have proved promising results during in vitro screening. An in vivo proof of concept, showing the protection of photoreceptors during light-induced stress on a murine model of macular degeneration, was obtained after IV administration of a lipophenol from the phloroglucinol-DHA series.

The proposed CDD will be carried out within the University of Montpellier (Faculty of Pharmacy), in the “Bioactive Lipids” Team (Dr. T. Durand) of the Institute of Biomolecules Max Mousseron, IBMM (Prof. P. Dumy ), under the supervision of Dr. Céline Crauste. The biological evaluations in cell culture will be done at the Institute of Neurosciences of Montpellier in the team of Dr. Philippe Brabet.


Contact to

Hiring/Funding Organisation/Institute

  • ORGANISATION/COMPANY

CNRS

  • DEPARTMENT

Institut des Biomolécules Max Mousseron

  • ORGANISATION TYPE

Public Research Institution

  • WEBSITE

http://pharmacie.edu.umontpellier.fr/

  • COUNTRY

France

  • CITY

MONTPELLIER




The metabolic control of cardiovascular differentiation of embryonic stem cells

  • ORGANISATION/COMPANY

International Giessen Graduate Centre for the Life Sciences

  • RESEARCH FIELD

Biological sciences › Biology

Medical sciences › Veterinary medicine

  • RESEARCHER PROFILE

First Stage Researcher (R1)

  • APPLICATION DEADLINE

04/03/2019 12:00 - Europe/Brussels

  • LOCATION

Germany › Giessen

  • TYPE OF CONTRACT

Temporary

  • OFFER STARTING DATE

15/04/2019

 

Stem cells will be used in regenerative medicine in the near future. To successfully apply stem cells in cell therapy approaches, the signaling cascades which underly formation of  organotypic, terminally differentiated cells have to be investigated in detail. In the current research project we will unravel how the cell metabolism of embryonic stem cells is regulating differentiation, maturation and aging  of cardiomyocytes as well as endothelial cells in newly formed blood vessels.  The student in this project will learn to differentiate cardiac cells and blood vessels from pluripotent stem cells and will analyze their cellular function. He/she will investigate how the interplay between glycolysis and fatty acid oxidation regulates cardiovascular differentiation.

 

Contact to

Hiring/Funding Organisation/Institute

  • ORGANISATION/COMPANY

International Giessen Graduate Centre for the Life Sciences

  • ORGANISATION TYPE

Higher Education Institute

  • WEBSITE

http://www.uni-giessen.de/ggl

  • COUNTRY

Germany

  • CITY

Giessen

  • POSTAL CODE

35392

  • STREET

Leihgesterner Weg 52

 

PhD position: Novel organoselenium coumpounds: From the heart of the tuna fish to antioxidant capacity via intricate nitric oxide signaling – SeleNOx

  • ORGANISATION/COMPANY

Université de lorraine

  • RESEARCH FIELD

Biological sciences › Biology

Chemistry › Organic chemistry

Pharmacological sciences › Pharmacy

  • RESEARCHER PROFILE

First Stage Researcher (R1)

  • APPLICATION DEADLINE

30/04/2019 23:00 - Europe/Brussels

  • LOCATION

France › Nancy
Germany › Saarbruecken

  • TYPE OF CONTRACT

Temporary

  • JOB STATUS

Full-time

  • HOURS PER WEEK

35

  • OFFER STARTING DATE

02/09/2019


 

Novel organoselenium coumpounds: From the heart of the tuna fish to antioxidant capacity via intricate nitric oxide signaling – SeleNOx


  • ORGANISATION/COMPANY

Université de lorraine

  • RESEARCH FIELD

Biological sciences › Biology

Chemistry › Organic chemistry

Pharmacological sciences › Pharmacy

  • RESEARCHER PROFILE

First Stage Researcher (R1)

  • APPLICATION DEADLINE

30/04/2019 23:00 - Europe/Brussels

  • LOCATION

France › Nancy
Germany › Saarbruecken

  • TYPE OF CONTRACT

Temporary

  • JOB STATUS

Full-time

  • HOURS PER WEEK

35

  • OFFER STARTING DATE

02/09/2019



PhD supervisors

Dr Caroline GAUCHER, HDR, CITHEFOR, Faculty of Pharmacy, Université de Lorraine (UL), France

Pr Claus JACOB, Division of Bioorganic Chemistry School of Pharmacy, Saarland University, Germany

Co-supervisor: Dr Caroline PERRIN-SARRADO, CITHEFOR, Faculty of Pharmacy, UL, France

DESCRIPTION

In recent years, a particular interest has been given to organoselenium compounds as antioxidants, regulating free radical reactions in the organism, and mimicking glutathione peroxidase (GPx) activity1-4. In contrast to popular opinion, organoselenium compounds are not “artificial” or alien to Biology. They are often “natural”, found, for instance, as selenoneine, the major form of organic selenium in tuna5, or as selenoproteins, such as the GPx family and the thioredoxin reductase (TrxR) in mammals6,7. Indeed, in selenoproteins, the selenocysteine residue with a selenol (–SeH) group exhibits superior redox properties compared to the thiol group of the cysteine residue8. This activity has been mimicked by small molecule catalysts, and ebselen, the flagship organoselenium-based mimic, exhibits moderate GPx-like catalytic activity attributed to thiol exchange reactions, which protects thiol groups of proteins from oxidation. Even if ebselen shows low solubility in aqueous medium - hence generally limiting pharmaceutical applications - it is currently being investigated in clinical trials for Meniere's disease (Phase 2, US) and for bipolar disorder (Phase 2, UK). From a physiological perspective, the interaction of selenium with nitric oxide (NO) is particularly stimulating. Ebselen derivatives have been used as a cover of medical devices to release NO from blood circulating S-nitrosothiols (RSNOs) in the presence of cysteine9. NO released from this type of catalysis shows antithrombotic properties. Indeed, NO is an endogenous radical implicated into vascular homeostasis, responsible for antithrombotic properties to vasodilation. RSNOs, such as S-nitrosoglutathione (GSNO), are the main storage forms of this highly reactive gasotransmitter in tissues10. We recently demonstrated that NO released from GSNO protects cysteine residues of proteins from oxidation in vascular smooth muscle cells11.

Since both, selenium compounds and NO-releasing agents, seem to protect cysteine residues, a joint action of these two prominent “antioxidants” may be particularly effective. The aim of this project therefore is to develop such “double impact” molecules which combine the catalysis of selenium with NO release, and hence counteract vascular oxidative stress particularly efficiently. From a chemical perspective, such small molecule organoselenium compounds are not only feasible and may indeed be modelled on naturally occurring selenonine, they may also provide additional benefits, such as higher aqueous solubility and GPx-activity than ebselen. Indeed, the redox-modulating thiol exchange properties of these selenoderivatives will be employed to stimulate the release of NO from physiological RSNOs. In this perspective, the organoselenium compounds developed as part of this project could counteract oxidative stress and restore the NO pool, which both are highly beneficial events in cardiovascular disease and, in the medium term, could promote the therapeutic applications of these drug candidates in association with RSNOs.

Aims and Methods

The programme is designed to provide expert multidisciplinary training in synthetic chemistry and in biology, in two phases and at two sites within the UGR. In the first phase, the PhD student, with the help of C. JACOB (Professor) and Y NEY, A KHARMA (senior PhD students) will synthesize and, by physico-chemical analytical techniques characterize a range of around ten new organoselenium compounds. These compounds will be designed to be stable and soluble in a physiological environment. They will become activated in the presence of certain biomolecules, such as GSH. To verify independently the antioxidant power of these molecules, cyclic voltammetry experiments and antioxidant assays, such as the 2,2-diphenyl-1-picrylhydrazyl assay (DPPH)12, the FRAP assay and the Total Antioxidant Capacity Assay (TAC) will be carried out. The catalytic properties will be established in a GPx-assay based on hydrogen peroxide and thiophenol. The resulting selenium species will not only be redox-catalytic, they will also be highly nucleophilic and hence able to release NO from a range of carriers. Such Reactive Selenium Species will also exhibit their own pharmacological profiles once placed inside cells, and this can be studied with the assistance of “intracellular diagnostics”13. Together, the Division of Bioorganic Chemistry therefore will provide complementary experience, expertise, techniques and studies in the field of isolation, characterization, synthesis and analysis of agents, from natural products to complicated 77Se-NMR, electrochemistry, initial biological assays and FACS analysis as part of mode of action studies. Besides these important and central methods, the platform for “intracellular diagnostics” and various methods for nanosizing will also be available14,15{Griffin, 2018 #2}{Griffin, 2018 #2}{Griffin, 2018 #2}{Griffin, 2018 #2}{Griffin, 2018 #1}{Griffin, 2018 #1}{Griffin, 2018 #1}.

In the second phase, the PhD student will move to the UL. Here, and with the help of C. Gaucher (associate professor) and C. Perrin-Sarrado (associate professor), she/he will evaluate the GPx-like activity of each organoselenium compound synthesized in the presence of various oxidants and thiols. The most promising compounds will be evaluated in the in vitro model of oxidative stress induced by a radical generator on vascular smooth muscle cells11. This model showed a decrease of intracellular reduced thiol concentrations, as well as glutathione efflux and modifications of redox enzymes activity. Subsequently, the ability of organoselenium compounds to release NO from RSNO in the presence of a reducing agent will be evaluated using NO quantification methods already established by the French partner. The panel of intracellular S-nitrosated proteins will be identified to consider new pharmacological targets of NO. The most promising compounds will be evaluated for vaso-relaxing properties on rat aortic rings using an aorta bench available in the laboratory of the French partner. First, the potentialization of NO release from RSNO by selenocompounds will be translated in effective concentration 50 (EC50) and Emax values. Next, as the French partner already showed that RSNO can achieve the formation of a NO store within the vascular wall, the potentiality of selenocoumpounds to mobilize this NO store will be studied along vasorelaxation.


Contact to

Hiring/Funding Organisation/Institute

  • ORGANISATION/COMPANY

Université de lorraine

  • DEPARTMENT

Faculty of Pharmacy

  • ORGANISATION TYPE

Research Laboratory

  • WEBSITE

http://www.univ-lorraine.fr/

http://cithefor.univ-lorraine.fr/

https://www.uni-saarland.de/lehrstuhl/jacob/start.html

  • COUNTRY

France

  • CITY

Nancy

  • STREET

Rue A. Lebrun


Leonarda Buscemi

  • ORGANISATION/COMPANY

Università degli Studi di Palermo

  • RESEARCH FIELD

Biological sciences › Biodiversity

  • RESEARCHER PROFILE

First Stage Researcher (R1)

Recognised Researcher (R2)

Established Researcher (R3)

Leading Researcher (R4)

  • APPLICATION DEADLINE

15/03/2019 23:59 - Europe/Brussels

  • LOCATION

Italy

  • TYPE OF CONTRACT

To be defined

 

Research activities include the functional characterization of compounds extracted and fractionated from material obtained from the processing of citrus and oil. In order to verify its potential use as adjuvants in the treatment of pathologies characterized by an inflammatory component including neoplastic diseases, the extracts will be tested on in vitro models of hepatocarcinoma and on endothelial cell models to verify their ability to modulate the angiogenic process. The evaluation of the biological effects induced on such cellular models will be carried out by cell proliferation assays, apoptosis, analysis of structural changes (cytoskeletal changes and junctional systems) and analysis of the modulation of differentiation markers and of specific pathways in response to oxidative stresses. or inflammatory response.


Contact to

Hiring/Funding Organisation/Institute

  • ORGANISATION/COMPANY

Università degli Studi di Palermo

  • ORGANISATION TYPE

Public Research Institution

  • WEBSITE

http://http//portale.unipa.it

  • COUNTRY

Italy

  • CITY

Palermo

 

Post-doc

  • ORGANISATION/COMPANY

Nencki Institute of Experimental Biology

  • RESEARCH FIELD

Biological sciences

  • RESEARCHER PROFILE

Recognised Researcher (R2)

  • APPLICATION DEADLINE

11/03/2019 23:00 - Europe/Athens

  • LOCATION

Poland › Warsaw

  • TYPE OF CONTRACT

Temporary

  • JOB STATUS

Full-time

  • HOURS PER WEEK

40

  • OFFER STARTING DATE

01/04/2019

Scope of tasks:

The main aim of the project (The role of oxidative stress in the pathogenesis of Non-Alcoholic Fatty Liver Disease) is to disclose the hepatic redox alterations and the specific end-points for mitochondrial dysfunction that represent a point of no return and which drive the progression of Non-alcoholic fatty liver disease (NAFLD) towards Non-Alcoholic Steatohepatitis (NASH) in a nonreversible manner. Moreover we plan to investigate whether the returning back to the standard diet and/or administration of a new class of mitochondrial-targeted antioxidants to mice with already developed NAFLD or during its progression to NASH will have beneficial effect on mitochondrial metabolism and ROS homeostasis in the liver.

The tasks will include characterization of mitochondrial metabolism, bioenergetics, ROS production, the status of the antioxidant defense system as well as the presence of markers of oxidative damages in the liver of mice at different time-points of NAFLD development and its progression to NASH.

 

Further information can be obtained by contacting prof. Mariusz Więckowski (m.wieckowski@nencki.gov.pl).

Contact to

Hiring/Funding Organisation/Institute

  • ORGANISATION/COMPANY

Nencki Institute of Experimental Biology

  • DEPARTMENT

Laboratory of Bioenergetics and Biomembranes

  • ORGANISATION TYPE

Public Research Institution

  • WEBSITE

http://www.nencki.gov.pl

  • E-MAIL

u.dziewulska@nencki.gov.pl

  • COUNTRY

Poland

  • CITY

Warsaw

  • STREET

3 Pasteur St.



Postdoctoral Scientist

  • ORGANISATION/COMPANY

German Cancer Research Center in the Helmholtz Association (DKFZ)

  • RESEARCH FIELD

Biological sciences

Chemistry

Engineering

  • RESEARCHER PROFILE

First Stage Researcher (R1)

Recognised Researcher (R2)

Established Researcher (R3)

Leading Researcher (R4)

  • APPLICATION DEADLINE

08/03/2019 23:59 - Europe/Brussels

  • LOCATION

Germany › Heidelberg

  • TYPE OF CONTRACT

Other

  • JOB STATUS

Other



The German Cancer Research Center is the largest biomedical research institution in Germany. With approximately 3,000 employees, we operate an extensive scientific program in the field of cancer research.

The Division of *Redox Regulation* is seeking a

*Postdoctoral Scientist*
(Ref-No. 2019-0053)

*Description:*
We are seeking a postdoctoral researcher to join the Division of Redox Regulation at DKFZ, offering a highly interactive and collaborative scientific environment. We study the role of metabolically derived oxidants as messengers in signal transduction and the principles of protein redox regulation and stress adaptation in normal and tumor cells. We employ a broad range of techniques, ranging from live-cell imaging and genome engineering to proteomics and biochemistry. For more information please see our web page http://www.dkfz.de/en/redoxregulation/.

The position is part of an ERC-funded project that aims to systematically uncover, dissect, monitor and manipulate protein redox interactions that give specificity and efficiency to redox signaling. A combination of genetic screening, redox proteomics and transcription profiling will be employed to unravel the organization of redox signaling pathways, their target proteins und their functional impact on gene regulation. The project is expected to yield fundamental insights into the specific molecular links by which reactive oxygen, nitrogen and sulfur species couple changes in metabolism to cellular and organismal adaptations regulating resilience and health span. The position is designated for work with mammalian cells.

*Your profile:*
A PhD in biology / life sciences or biochemistry / chemistry, advanced knowledge of molecular biology, cell biology and/or biochemistry, and substantial laboratory experience are required. A background in redox biology is desired, but not essential.

The applicant should be highly self-motivated and be able to pursue research projects independently as well as in collaborations. An excellent written and oral command of English is essential.

Please submit your application in a single PDF file with CV, a letter stating research and career interests, transcripts of secondary school and university certificates, expected availability date, and 2-3 letters of reference.

The position is limited to 2 years with the possibility of prolongation.

The position can in principle be part-time.

*For further information* please contact PD Dr. Tobias Dick, phone +49 6221 42-2320.

The German Cancer Research Center is committed to increase the percentage of female scientists and encourages female applicants to apply. Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

To apply for a position please use our online application portal (www.dkfz.de).

We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personalabteilung, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.

Work location(s)

1 position(s) available at

German Cancer Research Center in the Helmholtz Association (DKFZ)

Germany

Heidelberg

EURAXESS offer ID: 381503
Posting organisation offer ID: 676617


Contact to

Hiring/Funding Organisation/Institute

  • ORGANISATION/COMPANY

German Cancer Research Center in the Helmholtz Association (DKFZ)

  • ORGANISATION TYPE

Other

  • WEBSITE

https://www.dkfz.de/en/index.html

  • COUNTRY

Germany

  • CITY

Heidelberg

Research Assistant/Associate

  • ORGANISATION/COMPANY

Newcastle University

  • RESEARCH FIELD

Biological sciences

Medical sciences

  • RESEARCHER PROFILE

Recognised Researcher (R2)

  • APPLICATION DEADLINE

30/03/2019 12:00 - Europe/London

  • LOCATION

United Kingdom › Newcastle upon Tyne

  • TYPE OF CONTRACT

To be defined

  • JOB STATUS

Full-time

  • HOURS PER WEEK

37

  • REFERENCE NUMBER

A193467R

 

We are looking to recruit an enthusiastic and highly motivated computational biologist to work in the laboratory of Dr Alberto Sanz at the Institute for Cell and Molecular Biology (Newcastle University, Newcastle upon Tyne, United Kingdom). The project will focus on investigating the role of mitochondrial Reactive Oxygen Species (ROS) in health and disease with a special focus on ageing.

You will work with fly models where ROS levels and/or mitochondrial function are manipulated to extend lifespan. You will investigate which genetic and epigenetic changes are instrumental to extend healthy lifespan. You will be in possession of a PhD (or imminent submission of thesis) or alternatively a Master (MSci, MRes or equivalent) in Bioinformatics, System Biology or a close related discipline. Substantial practical knowledge of analysis of next generation sequencing is essential, including transcriptomics, epigenomic profiling as well as integration with proteomics and metabolomics datasets. Priority will be given to those candidates with demonstrable experience in the ageing field and/or Drosophila melanogaster. You should have excellent communication skills and the ability to work independently and as part of a team.

Further information can be obtained by contacting Dr Alberto Sanz (email: alberto.sanz@ncl.ac.uk)

This post is tenable for (3 years with possibility of 2 years extension).

For informal enquiries, please contact: alberto.sanz@ncl.ac.uk

Institute web page: http://www.ncl.ac.uk/camb/

Lab web page: https://www.ncl.ac.uk/camb/staff/profile/albertosanz.html#background

Closing date: 30 March 2019

Newcastle University is committed to being a fully inclusive Global University which actively recruits, supports and retains staff from all sectors of society. We value diversity as well as celebrate, support and thrive on the contributions of all our employees and the community they represent. We are proud to be an equal opportunities employer and encourage applications from everybody, regardless of race, sex, ethnicity, religion, nationality, sexual orientation, age, disability, gender identity, marital status/civil partnership, pregnancy and maternity, as well as being open to flexible working practices.

 

The University holds a silver Athena SWAN award in recognition of our good employment practices for the advancement of gender equality. The University also holds the HR Excellence in Research award for our work to support the career development of our researchers, and is a member of the Euraxess initiative supporting researchers in Europe.

Please be advised that due to the minimum salary threshold of £30,000 per annum imposed by the UKVI, this post may not qualify for University sponsorship under Tier 2 of the points based system.

Contact to

Hiring/Funding Organisation/Institute

  • ORGANISATION/COMPANY

Newcastle University

  • DEPARTMENT

Institute for Cell and Molecular Biosciences - Dr Alberto Sanz

  • ORGANISATION TYPE

Research Laboratory

  • WEBSITE

https://www.ncl.ac.uk/camb/

  • E-MAIL

alberto.sanz@ncl.ac.uk

  • COUNTRY

United Kingdom

  • CITY

Newcastle upon Tyne

  • STATE/PROVINCE

Tyne and Wear

  • POSTAL CODE

NE2 4HH

  • STREET

Framlington Place

NATURE JOBS

Postdoctoral Fellow/Physiology - 190000001R

The University of Tennessee Health Science Center (UTHSC)

Postdoctoral Fellow/Physiology – 190000001R

Description

POSTDOCTORAL POSITION – Vascular Biology/Oxidative stress

Postdoctoral Fellow position is available in the Department of Physiology to study the effects of oxidative stress on the physiological functions of cerebral vessels in animal models of oxidative stress-induced cerebral vascular injury. We place particular emphasis on endogenously generated carbon monoxide and hydrogen sulfide as essential components of the antioxidant cytoprotection mechanism in the brain. We combine intravital microscopy in newborn piglets, isolated cerebral vessels, and primary cell cultures with molecular and biochemical approaches to identify mechanisms that promote survival of cerebral vascular cells and astrocytes during oxidative stress.

For more about Dr. Parfenova’s research and lab, please visit https://www.uthsc.edu/physiology/faculty/hparfeno.php

Qualifications

Experience with cultured cells, confocal microscopy, molecular biology, RT-PCR, Western immunoblotting, immunofluorescence, oxidative stress markers, mechanisms of cell death by apoptosis and autophagy, signal transduction, and biochemistry is preferred.

Required qualifications include a PhD or MD.

Send curriculum vitae, description of the research experience and names and addresses of three references to Dr. Helena Parfenova, Professor, Department of Physiology, at hparfeno@uthsc.edu.

Salary will be commensurate with relevant experience and is competitive for postdoctoral research fellows. The position includes an excellent benefits package (http://www.uthsc.edu/postdoc/benefits.php). Located in Memphis, a dynamic Mid-South city rich in culture, history, diversity, music and cuisine, the University of Tennessee Health Science Center is one of the largest, most comprehensive academic health centers in the United States with a solid commitment to postdoctoral training. UTHSC is an EEO/AA/Title VI/Title IX/Section 504/ADA/ADEA/V institution in the provision of its education and employment programs and services.

Job Postdoctoral Fellows

Primary Location US-Tennessee-Memphis

Organization Physiology

Campus/Institute – Memphis

Schedule – Full-time

Job Posting Jan 16, 2019, 6:58:52 AM

PhD position in “Characterization of the formation and aging of secondary organic aerosol (SOA) from complex real plant emissions under varying environmental conditions”

Work group:

IEK-8 - Troposphäre


Area of research:

PHD Thesis


Job description:

Your Job:

The PhD project is part of the AeroHEALTH Helmholtz International Lab which is a German-Israeli research initiative, investigate the complex interplay of atmospheric aerosol formation, composition and aging and their health effects. AEROHealth is an international platform combining expertise from fields of atmospheric research and exposure and health effect assessment of aerosols to various exposure models. The formation and the composition of PM is very complex with up to 80% of the fine particulate matter forming due to atmospheric oxidation processes of gas phase precursors (secondary organic aerosols (SOA)). On a global scale the emissions of biogenic volatile organic compounds (BVOCs) by plants are an order of magnitude higher than those of anthropogenic origin. Thus they significantly contribute to atmospheric processes and SOA formation and composition. The target of this PhD project focuses on the investigation of the transformation of organic aerosols formed from complex real plant emissions using the Plant Unit for Simulation (PLUS) in combination with the atmosphere simulation chamber SAPHIR.

In-situ measurements using high resolution mass spectrometry methods to determine physical and chemical properties (e.g. chemical bulk parameters like oxygen to carbon ration) of atmospheric aerosols The studies will be conducted using the plant chamber SAPHIR-PLUS which allows for controlled variations of plant conditions to possible future scenarios (e.g. effects of stress induced emissions (SIE)) Characterization of chemical aging of SOA from real plant emissions close to real atmospheric conditions concerning precursor concentration and yields using natural sunlight Investigation of the effect of parameters likes different oxidants (daytime and nighttime oxidation) and SOA formation from constitutive and SIE of different tree species In cooperation with the partners of the AEROHealth international lab selected system will be studied in detail concerning their health effects

Your Profile:

M.Sc. degree in physics, chemistry, atmospheric sciences or a related field Knowledge about mass spectrometry and physical or analytical chemistry is advantageous Interest in process modelling is welcome Good skills in the spoken and written English language

Our Offer:

Exciting working environment on an attractive research campus with excellent infrastructure, located between the cities of Cologne, Düsseldorf, and Aachen International and interdisciplinary working atmosphere Broad spectrum of training in the Graduate School HITEC www.hitec-graduate-school.de and the Forschungszentrum The PhD work will be done within a three-year program of the Graduate School HITEC Salary analogous to EG 13 (50%) of the Collective Agreement for the Civil Service (TVöD)

We also welcome applications from disabled persons.


Postdoctoral Position – Structural Biologist/Biochemist – DNA Repair

University of Florida

Postdoctoral Position – Structural Biologist/Biochemist – DNA Repair

The Caglayan lab in the Department of Biochemistry and Molecular Biology, University of Florida seek an outstanding individual with Ph.D. training in biochemistry and/or structural biology to study the DNA repair.

The NIH-funded research project will focus on studying genome stability and oxidative stress-induced DNA damage processing. For more information, please see the lab website at https://caglayan.biochem.med.ufl.edu

Job Description
Duties will include:
Supporting projects through original research, collaboration with other team members, interpreting and critically evaluating primary literature; collection and analysis of data; and maintaining a complete, accurate, and up-to-date lab notebook; preparing and editing manuscripts for publication as well as applications for grants; attending an annual meeting to disseminate research findings and progress;

supervising and training of graduate students (PhD and Master’s level) and undergraduates. Applicants should have excellent communication and problem-solving skills and the ability to work flexible hours depending on specific experiments.

The Caglayan group is in both the Department of Biochemistry and Molecular Biology, and UF Health Cancer Center with investigators renowned for their contributions to the area of biochemistry and cancer biology. This exceptional training environment offers a highly supportive and collaborative scientific experience in many diverse areas of expertise.

Selected Publications
1)
Caglayan M. and Wilson S.H. Pol μ dGTP mismatch insertion opposite T coupled

with ligation reveals a promutagenic DNA intermediate during double strand break repair. Nature Communications (2018) 9: 4213.
2)
Caglayan M., Prasad R., Krasich R., Longley M.J., Kadoda K., Tsuda M., Sasanuma H., Takeda S., Tano K., Copeland W.C., Wilson S.H. Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts. Nucleic Acids Research (2017) 17: 10079 – 10088.
3)
Caglayan M., Wilson S.H. Role of DNA polymerase β oxidized nucleotide insertion in DNA ligation failure. Journal of Radiation Research (2017) 1093: 1 – 5.
4)
Caglayan M., Horton J.K., Da-Peng D., Stefanick D.F., Wilson S.H. Oxidized nucleotide insertion by pol β confounds ligation during base excision repair. Nature Communications (2017) 8: 14045.
5)
Caglayan M., Wilson S.H. Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair. DNA Repair (2015) 35: 85 – 89.
6)
Caglayan M., Horton J.K., Prasad R., Wilson S.H. Complementation of aprataxin deficiency by base excision repair enzymes. Nucleic Acids Research (2015) 43: 2271 – 2281.
7)
Caglayan M., Batra V.K., Sassa A., Prasad R., Wilson S.H. Role of polymerase β in complementing aprataxin deficiency during abasic-site base excision repair. Nature Structural and Molecular Biology (2014) 21: 497 – 499.

Minimum Requirements
PhD, MD, or PhD/MD degree in a related discipline.

Preferred Qualifications
The candidate should have experience in biochemistry, enzymology, and structural biology. Previous working experience with evidence of experimental skills related to X-ray crystallography and/or Cryo-EM with DNA repair proteins is preferred.

Advertised Salary
The salary for this position is commensurate with experience as determined by NIH guidelines.

Special Instructions to Applicants:
All applicants must also apply through the Careers at UF posting https://apply.interfolio.com/59230.

 

CSC PhD position for the study of redox sensitive proteins in plants

VIB

 

Location

VIB is one of the leading life science research and innovation institutes in Europe. It is based on a cooperation between 5 Belgian Universities including VUB in Brussels. The Messens lab at VIB-VUB is a world leader in the redox field with a strong track record of high-impact publications. The lab provides a cutting-edge protein biochemistry and structural biology research environment in a highly dynamic and team-oriented international research group tackling essential biological problems in redox signaling.

Position

A PhD position is immediately available in the Messens lab Center for Structural Biologyin Brussels, Belgium for a well-qualified student who will apply and is awarded a Chinese Scholarship Council (CSC) grant in protein biochemistry and structural biology.

Mission of the lab

The Messens lab decipher how cells sense redox metabolites and transduce these stimuli into downstream biological effects. Knowledge of the mechanisms by which sensors and transducers function are invaluable in understanding how redox homeostasis pathways can be engineered. This in turn provides ways to improve oxidative stress resistance in plants and to identify therapeutic targets for diseases such as diabetes and cancer.

The PhD project 

The project, as part of the Excellent of Science (EOS)-project ‘Organellar Redox Signaling in Plants’, will focus on structure-function studies of plant proteins that participate in redox signaling cascades. The student will address vital outstanding biological problems in plant redox signaling. This exciting project will likely yield high-caliber results suitable for publication in top journals. 

Requirements

Applicants should have obtained a Master of Science degree with great or greatest distinction. Expertise in molecular biology, protein biochemistry, biophysical techniques and enzymology is essential, as well as fluency in English. Knowledge of plant physiology is an asset. We will finance you with an EOS-fellowship, and support your CSC fellowship application.

How to apply?

Motivated candidates are asked to apply online.

Please include a cover letter discussing your interests in our lab and projects as well as your CV and a list of 3 individuals as references when applying. 


 

The Society for Free Radical Research - Europe (SFRR-E) is dedicated to promoting interest in all aspects of of research related to Free Radicals in any scientific field.

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