Negre-Salvayre Anne

Abbreviated C.V.
Anne Nègre-Salvayre, Pharm. D, Ph.D, Research Director INSERM UMR1048 - Institute of Metabolic and Cardiovascular Diseases CHU Rangueil, BP84221 31432 - Toulouse Cedex 4, France Tel/Fax +33 561 322 059 Email: Biography Dr. Anne Negre-Salvayre is Pharmacist, Medical Biologist, Pharm. D and Ph.D, Graduate of the University Paul Sabatier in Toulouse, France. She first served as Medical Instructor in Biochemistry at Toulouse-Purpan Hospital, and assistant-professor in Physiology at the Faculty of Medicine-Rangueil in Toulouse. After several postdoctoral stays at the Hadassah Medical School in Jerusalem, Israel, she entered CNRS as research fellow (CR) in 1985, first in the INSERM Unit 101 (Pr. Louis Douste-Blazy), then in the INSERM Unit 466 (Director Pr. Robert Salvayre). Currently, she holds the position of research director (DR1) and is team-leader of the INSERM team " Lipid Peroxidation Signalling and Vascular Diseases " since 2006 at INSERM Unit 1048, Institute of Metabolic and Cardiovascular Diseases (Director Pr. Angelo Parini), Toulouse, France. Dr. Negre-Salvayre is author or co-author of more than 200 PubMed-indexed publications and national or international communications. Her H-Index is 58, source Web of Science (Negre-Salvayre or NegreSalvayre or Salvayre a). She is Associate Editor for the British Journal of Pharmacology, Free Radical Research, Antioxidants, and Free Radicals in Biology and Medicine. She is expert or external referee for international academic and non-academic councils including INSERM, HCERES, FDG German Research Fundation, Israel Science Fundation, Medical Research Council. She is member of The New French Society for Atherosclerosis, the french Reflection group on Cardiovascular Research, the Society for Free Radical Research and the 4-HNE-Club. Dr. Negre-Salvayre is expert in the field of lipid and sphingolipid biochemistry, lipid peroxidation and oxidative stress in the pathophysiology of atherosclerosis.

Selected publications

1/ Augé, N., Fitoussi, G., Bascands, J.L., Pieraggi, M.T., Junquero, D., Valet, P., Girolami, J.P., Salvayre, R., Nègre-Salvayre, A. Oxidized LDL evoke a sustained calcium-dependent contraction of vascular smooth muscle cells. Circ. Res. 1996, 79, 871-880.
2/ Escargueil-Blanc,I., Vacaresse, N., Jürgens, G., Darblade, B., Arnal, J. F., Parthasarathy, S., Salvayre, R., Negre-Salvayre, A. Oxidized LDL induced-activation of PDGF-Receptor. Circulation, 2001, 104, 1814-21.
3/ Portero-Otin, M., Pamplona, R., Bellmunt, M. J., Ruiz, M. C., Prat, J., Thorpe, S., Salvayre, R., Negre-Salvayre, A. Maillard reaction-derived -oxoaldehydes inhibit EGFR signalling. Diabetes. 2002, 51, 1535-42.
4/ Nathalie Augé, Françoise Maupas-Schwalm, Meyer Elbaz, Jean-Claude Thiers, Axel Waysbort, Shigeyoshi Itohara, Hans-Willi Krell, Robert Salvayre, Anne Nègre-Salvayre. A role for Matrix MetalloProteinase-2 in oxidized LDL-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation. Circulation, 2004, 110, 571-8.
5/ Maupas-Schwalm F, Robinet C, Augé N, Thiers JC, Garcia V, Cambus JP, Salvayre R, Nègre-Salvayre A. -catenin regulates cyclin D1 expression and cell proliferation mediated by tissue-type Plasminogen Activator. Cancer Res. 2005 Jan 15;65(2):526-32.
6/ Fischer J, Lefèvre C, Morava E, Mussini JM, Laforêt P, Negre-Salvayre A, Lathrop M, Salvayre R. The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy. Nat Genet. 2007 Jan;39(1):28-30.
7/ Sanson M, Augé N, Vindis C, Muller C, Bando Y, Thiers JC, Marachet MA, Zarkovic K, Sawa Y, Salvayre R, Nègre-Salvayre A. Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression. Circ Res. 2009, 104:328-36.
8/ Galvani S, Trayssac M, Augé N, Thiers JC, Calise D, Krell HW, Sallusto F, Kamar N, Rostaing L,Thomsen M, Nègre-Salvayre A, Salvayre R. A key role for matrix metalloproteinases and neutral sphingomyelinase-2 in transplant vasculopathy triggered by anti-HLA antibody. Circulation. 2011;124(24):2725-34.
9/ Larroque-Cardoso P, Camaré C, Nadal-Wollbold F, Grazide MH, Pucelle M, Garoby-Salom S, Bogdanowicz P, Josse G, Schmitt AM, Uchida K, Zarkovic K, Salvayre R, Nègre-Salvayre A. Elastin Modification by 4-Hydroxynonenal in Hairless Mice Exposed to UV-A. Role in Photoaging and Actinic Elastosis. J Invest Dermatol. 2015;135(7):1873-81.
10/ Guerby P, Swiader A, Augé N, Parant O, Vayssière C, Uchida K, Salvayre R, Negre-Salvayre A. High glutathionylation of placental endothelial nitric oxide synthase in preeclampsia. Redox Biol. 2019;22:101126.