Fulvio Ursini

Abbreviated C.V.
Fulvio Ursini Professor of Biochemistry 1978-1980. Assistant Professor of Biochemistry, Padova University Medical School. 1980-1990. Associate Professor of Applied Biochemistry, Padova University, School of Medicine. 1992-1994. Member of the Scientific Committee of International Life Sciences Institute, Bruxelles, Belgium 1985. Visiting Professor at the Department for Toxicology and Biochemistry, University of Southern California, Los Angeles 1990-1996. Full Professor of Biochemistry, School of Food Science and Technology, University of Udine, Italy 1996-presently. Full Professor of Biochemistry, School of Medicine, University of Padova, Italy 2003-2012. Adjunct Professor of Biochemistry, Department of Molecular Pharmacology & Toxicology, School of Pharmacy, USC, Los Angeles USA 2005-2011. Director of the Department of Biological Chemistry, University of Padova 2012-2015. Vice-Director of the Department of Molecular Medicine, University of Padova 1997. "Klaus Schwarz commemorative Medal". Award of the "Association of Bioinorganic Scientist" for the research on Selenium. Baden-Baden, Germany. Fulvio Ursini, born 1951, serves as professor of biochemistry, School of Medicine, University of Padova. The leitmotif of its studies has been the mechanism of antioxidant effect. These studies led to the discovery of the selenoenzyme GPx4, the functional inactivation of which activates lipid peroxidation and a regulated form of cell death named ferroptosis. He described the chemistry of the functional interaction between enzymatic antioxidant systems-reducing hydroperoxides and chain breaking antioxidants reducing lipid hydroperoxyl radicals. This interplay between a nucleophilic displacement reaction and free radical scavenging contributed to bridging the gap between chemistry and cell biology of free radical oxidations in biology. In the frame of studies on antioxidant mechanisms, he unraveled the role of GPx4 in protein oxidation required for spermatogenesis. This clarified the role of selenium catalysis in male fertility. He first described the post-prandial oxidative stress and the protective role of foods containing nucleophiles (such as wine or beer). The pathophysiological outcome of these studies led to the description of an innovative modification of LDL, where a misfolding of a specific loop of ApoB, where the shift from alpha to beta structure leads to the formation toxic amyloid like aggregates compatible with an atherogenic effect.

Selected publications

THE SELENOENZYME PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE-PEROXIDASE‎ By: Ursini, F; Maiorino, M; Gregolin, C. BIOCHIMICA ET BIOPHYSICA ACTA  Volume: ‏ 839   Issue: ‏ 1   Pages: ‏ 62-70   Published: ‏ 1985
DIVERSITY OF GLUTATHIONE PEROXIDASES‎ By: Ursini, F; Maiorino, M; Brigeilius- Flohè, R; et al. ‏METHODS IN ENZYMOLOGY   Volume: ‏ 252   Pages: ‏ 38-53   Published: ‏ 1995
LDL(-) is a lipid hydroperoxide-enriched circulating lipoprotein‎ By: Sevanian, A; BittoloBon, G; Cazzolato, G; et al. JOURNAL OF LIPID RESEARCH  Volume: ‏ 38   Issue: ‏ 3   Pages: ‏ 419-428   Published: ‏ MAR 1997
Postprandial plasma lipid hydroperoxides: A possible link between diet and atherosclerosis‎ By: Ursini, F; Zamburlini, A; Cazzolato, G; et al. FREE RADICAL BIOLOGY AND MEDICINE  Volume: ‏ 25   Issue: ‏ 2   Pages: ‏ 250-252   Published: ‏ JUL 15 1998
Dual function of the selenoprotein PHGPx during sperm maturation‎ By: Ursini, F; Heim, S; Kiess, M; et al. SCIENCE  Volume: ‏ 285   Issue: ‏ 5432   Pages: ‏ 1393-1396   Published: ‏ AUG 27 1999
Atherosclerosis: another protein misfolding disease? By: Ursini, F; Davies KJA; Maiorino, M; et al. TRENDS IN MOLECULAR MEDICINE  Volume: ‏ 8   Issue: ‏ 8   Pages: ‏ 370-374   Article Number: PII S1471-4914(02)02382-1   Published: ‏ AUG 2002
How do nutritional antioxidants really work: Nucleophilic tone and para-hormesis versus free radical scavenging in vivo‎ By: Forman, Henry J.; Davies, Kelvin J. A.; Ursini, Fulvio FREE RADICAL BIOLOGY AND MEDICINE  Volume: ‏ 66   Special Issue: ‏ SI   Pages: ‏ 24-35   Published: ‏ JAN 8 2014
Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis‎ By: Ingold, Irina; Berndt, Carsten; Schmitt, Sabine; et al. CELL  Volume: ‏ 172   Issue: ‏ 3   Pages: ‏ 409-+   Published: ‏ JAN 25 2018
A dual attack on the peroxide bond. The common principle of peroxidatic cysteine or selenocysteine residues By: Dalla Tiezza, M.; Bickelhaupt, F. M.; Flohe, L.; et al. REDOX BIOLOGY  Volume: ‏ 34     Article Number: UNSP 101540   Published: ‏ JUL 2020
Lipid peroxidation and ferroptosis: The role of GSH and GPx4 By: Ursini, Fulvio; Maiorino, Matilde FREE RADICAL BIOLOGY AND MEDICINE  Volume: ‏ 152   Pages: ‏ 175-185   Published: ‏ MAY 20 2020